Table 2.

Associations between hemochromatosis, iron-overload anemias, and NACLD with pancreatic cancer in the SEER-Medicare 1992–2015a.

First primary pancreatic cancerLater primaries pancreatic cancerAll primaries pancreatic cancer
Conditions(N = 61,081)(N = 18,993)(N = 80,074)
Hemochromatosis
Model 1 OR (95% CI)b1.08 (0.89–1.31)1.06 (0.76–1.46)1.07 (0.91–1.26)
Model 2 OR (95% CI)c1.04 (0.86–1.26)1.05 (0.76–1.46)1.04 (0.88–1.23)
Sideroblastic anemia
Model 1 OR (95% CI)b1.00 (0.85–1.18)1.33 (1.06–1.68)1.10 (0.97–1.26)
Model 2 OR (95% CI)c0.93 (0.79–1.09)1.30 (1.03–1.64)1.04 (0.91–1.18)
Congenital dyserythropoietic anemia
Model 1 OR (95% CI)b0.99 (0.86–1.13)1.16 (0.95–1.42)1.04 (0.93–1.17)
Model 2 OR (95% CI)c0.95 (0.83–1.10)1.13 (0.92–1.38)1.01 (0.90–1.13)
NACLD
Model 1 OR (95% CI)b1.21 (1.12–1.32)1.27 (1.11–1.46)1.23 (1.15–1.32)
Model 2 OR (95% CI)c1.10 (1.01–1.19)1.17 (1.02–1.35)1.12 (1.04–1.20)
Liver cirrhosis
  Model 1 OR (95% CI)b1.20 (1.04–1.38)1.20 (0.95–1.51)1.20 (1.07–1.35)
  Model 2 OR (95% CI)c1.08 (0.94–1.25)1.10 (0.87–1.40)1.09 (0.97–1.23)
Fatty liver disease
  Model 1 OR (95% CI)b1.22 (1.08–1.38)1.34 (1.10–1.64)1.26 (1.13–1.39)
  Model 2 OR (95% CI)c1.10 (0.97–1.24)1.24 (1.02–1.52)1.14 (1.02–1.26)
  • Abbreviation: NACLD, non–alcoholic-related chronic liver disease.

  • aFirst primary pancreatic cancer was defined as pancreatic cancer occurring as a first malignancy and later primaries pancreatic cancer were defined as primary pancreatic cancer occurring as second or third malignancy between 1992 and 2015. International Classification of Diseases – 9th edition included: hemochromatosis (275.0, 275.01, and 275.03), sideroblastic (ICD-9 285.0), and congenital dyserythropoietic (ICD-9 285.8) anemias and NACLD (ICD-9 571.4, 571.41, 571.42, 571.49, 571.5, 571.6, 571.8, and 571.9).

  • bAdjusted for age category (66–69, 70–74, 75–79, 80–84, 85–89, 90–94, and 95–99 years); sex (men vs. women); calendar year of selection (1992–2000, 2001–2005, 2006–2009, 2010–2015); race/ethnicity (non-Hispanic white, non-Hispanic black, Asian/Pacific Islander, Hispanics, and other/unknown); SEER registry; average number of physician visits (quintiles); Medicaid/low-income subsidy (ever, never, unknown); average duration of Medicare Part A, B, or non-HMO coverage (quintiles); overweight/obesity (yes vs. no); smoking behavior-related diagnosis (yes vs. no); chronic obstructive pulmonary disease (yes vs. no); alcohol-related diagnosis (yes vs. no); and CLD (yes vs. no).

  • cAdditionally adjusted for type 2 diabetes mellitus (yes vs. no) and pancreatitis (yes vs. no).