Table 2.

Ten-year cumulative incidence proportion [per mille (‰)] of hepatobiliary cancer–related deaths in patients with ulcerative colitis.

Hepatocellular carcinomaIntrahepatic cholangiocarcinomaExtrahepatic cholangiocarcinoma
Ulcerative colitisComparatorsUlcerative colitisComparatorsUlcerative colitisComparators
Total0.5 (0.30.6)0.3 (0.20.3)0.6 (0.40.7)0.1 (0.10.1)0.4 (0.30.6)0.1 (0.10.2)
Sweden0.5 (0.30.7)0.3 (0.20.3)0.6 (0.40.8)0.1 (0.10.2)0.6 (0.40.8)0.2 (0.10.2)
Denmark0.5 (0.20.7)0.2 (0.20.3)0.4 (0.20.6)0.1 (0.10.2)0.1 (0.00.2)0.1 (0.00.1)
Sex
 Female0.2 (0.00.3)0.1 (0.10.1)0.3 (0.20.5)0.1 (0.10.2)0.3 (0.10.4)0.1 (0.10.2)
 Male0.8 (0.51.0)0.4 (0.30.5)0.8 (0.51.0)0.1 (0.10.1)0.6 (0.40.9)0.1 (0.10.2)
Age at first IBD diagnosis (y)
 <18Too few eventsToo few events0.4 (0.00.9)0.0 (0.00.0)0.0 (0.00.0)0.0 (0.00.0)
 18 to <400.1 (0.00.3)0.0 (0.00.0)0.4 (0.20.6)0.0 (0.00.0)0.4 (0.20.6)0.0 (0.00.0)
 40 to <600.8 (0.41.2)0.3 (0.20.4)0.6 (0.30.9)0.1 (0.10.2)0.5 (0.20.8)0.1 (0.10.1)
 ≥600.8 (0.41.3)0.8 (0.60.9)0.9 (0.51.4)0.4 (0.30.5)0.6 (0.31.0)0.5 (0.40.6)
Year of first diagnosis
 2003–20170.3 (0.10.4)0.3 (0.20.4)0.4 (0.20.7)0.1 (0.10.2)0.2 (0.10.4)0.1 (0.10.2)
 1990–20020.3 (0.10.5)0.2 (0.20.3)0.6 (0.30.8)0.1 (0.10.2)0.6 (0.30.8)0.1 (0.10.2)
 1977–19890.7 (0.31.2)0.3 (0.20.4)0.5 (0.20.9)0.0 (0.00.1)0.4 (0.10.7)0.2 (0.10.2)
 1969–19762.4 (0.64.2)0.5 (0.20.8)1.0 (0.02.2)0.0 (0.00.1)0.7 (0.01.6)0.1 (0.00.2)
Montreal classification
 E1 (ulcerative proctitis)0.0 (0.00.0)0.3 (0.20.5)0.1 (0.00.3)0.2 (0.10.4)0.3 (0.00.7)0.1 (0.10.2)
 E2 (left-sided colitis)0.0 (0.00.0)0.3 (0.10.4)0.3 (0.00.7)0.1 (0.00.2)0.4 (0.00.8)0.2 (0.10.3)
 E3 (extensive colitis)0.6 (0.30.8)0.2 (0.20.3)1.7 (1.32.2)0.1 (0.10.2)1.0 (0.61.4)0.1 (0.10.1)
 EX (extent not defined)0.6 (0.21.0)0.4 (0.30.4)0.9 (0.51.4)0.1 (0.10.2)0.9 (0.41.3)0.1 (0.10.2)
Extraintestinal manifestations
 Primary sclerosing cholangitis6.7 (3.59.9)0.3 (0.10.5)26.2 (19.932.5)0.1 (0.00.3)17.2 (12.222.2)0.1 (0.00.2)
 Other extraintestinal manifestations0.6 (0.01.1)0.4 (0.20.5)1.0 (0.31.8)0.1 (0.00.2)0.7 (0.11.3)0.1 (0.00.2)
Surgery during follow-up
 Total colectomy1.1 (0.51.7)0.2 (0.10.3)0.9 (0.31.5)0.0 (0.00.1)0.5 (0.10.9)0.1 (0.00.2)
 Other intestinal resections1.0 (0.31.6)0.1 (0.10.2)0.6 (0.11.1)0.0 (0.00.1)0.9 (0.31.5)0.1 (0.00.2)
 Perianal surgery0.0 (0.00.0)0.2 (0.00.5)Too few eventsToo few eventsToo few eventsToo few events
  • Note: Numbers in parentheses are 95% confidence intervals.