Table 2.

Summary of iBRI results for association between DNA repair subpathways and colorectal cancer risk.

KY (1,054 cases; 1,637 controls)CCFR (1,132 cases; 1,179 controls)MECC (141 cases; 150 controls)
SubpathwaySummary BFiBRIaGenesbVariantscBFiBRIdGenesVariantsBFiBRIGenesVariantsBFiBRI
ATM0.23151400.14151360.05124128.76
BER0.04241310.39241330.0917301.03
FA/HR0.67322700.213427020.1330780.16
MMR0.3291181.3391010.128252.04
NER36.961510911.59121014.3710270.73
NHEJ437.85963121.949619.26690.39
OTHER2.0911570.1710521.378118.97
RECQ0.14580.184580.324241.72
TLS1.959820.3611764.310271.28
XLR1.014541.24541.113190.75
  • aSummary BF from the iBRI method calculated by the product of the three study-specific BFs (KY, CCFR, MECC).

  • bNumber of genes in the subpathway.

  • cNumber of variants in the subpathway.

  • dStudy-specific BF from the iBRI method.