Table 3.

Ten-year cumulative incidence proportion [per mille (‰)] of hepatobiliary cancer–related deaths in patients with Crohn's disease.

Hepatocellular carcinomaIntrahepatic cholangiocarcinomaExtrahepatic cholangiocarcinoma
Crohn's diseaseComparatorsCrohn's diseaseComparatorsCrohn's diseaseComparators
Total0.3 (0.10.5)0.2 (0.20.3)0.1 (0.00.2)0.1 (0.10.1)0.3 (0.10.5)0.1 (0.10.1)
Sweden0.4 (0.20.6)0.2 (0.20.3)0.2 (0.00.3)0.1 (0.10.2)0.3 (0.10.5)0.1 (0.10.2)
Denmark0.1 (0.00.2)0.2 (0.10.2)−0.0 (0.00.0)0.1 (0.00.1)Too few eventsToo few events
Sex
 Female0.0 (0.00.1)0.2 (0.10.2)0.1 (0.00.2)0.1 (0.10.2)0.2 (0.00.3)0.1 (0.00.1)
 Male0.6 (0.21.0)0.2 (0.20.3)0.2 (0.00.4)0.1 (0.00.1)0.5 (0.20.8)0.1 (0.10.2)
Age at first IBD diagnosis (y)
 <18Too few eventsToo few eventsToo few eventsToo few eventsToo few eventsToo few events
 18 to <400.1 (0.00.3)0.0 (0.00.1)−0.0 (0.00.0)0.0 (0.00.1)0.1 (0.00.3)0.0 (0.00.0)
 40 to <600.5 (0.10.9)0.3 (0.20.4)0.4 (0.00.9)0.1 (0.00.2)0.4 (0.00.8)0.2 (0.10.2)
 ≥600.6 (0.01.2)0.7 (0.50.9)0.1 (0.00.4)0.4 (0.20.5)0.9 (0.21.7)0.4 (0.20.5)
Year of first diagnosis
 2003–20170.1 (0.00.2)0.3 (0.20.4)0.2 (0.00.4)0.1 (0.10.2)0.2 (0.00.4)0.1 (0.00.1)
 1990–20020.4 (0.10.7)0.1 (0.10.2)0.2 (0.00.4)0.1 (0.00.1)0.5 (0.20.9)0.1 (0.10.2)
 1977–19890.4 (0.00.8)0.2 (0.10.2)−0.0 (0.00.0)0.0 (0.00.1)0.1 (0.00.4)0.1 (0.00.2)
 1969–19760.8 (0.01.9)0.5 (0.20.8)−0.0 (0.00.0)0.2 (0.00.4)−0.0 (0.00.0)0.2 (0.00.3)
Montreal classification
 L1 (ileal)0.2 (0.00.5)0.2 (0.10.3)0.6 (0.21.1)0.1 (0.00.2)−0.0 (0.00.0)0.1 (0.00.1)
 L2 (colonic)0.3 (0.00.6)0.2 (0.10.3)0.4 (0.00.7)0.1 (0.10.2)0.7 (0.21.2)0.1 (0.00.1)
 L3/LX (ileocolonic/not defined)1.1 (0.51.7)0.2 (0.10.3)0.5 (0.11.0)0.1 (0.10.2)0.3 (0.00.7)0.1 (0.10.2)
Extraintestinal manifestations
 Primary sclerosing cholangitisToo few eventsToo few events19.0 (7.830.1)0.2 (0.00.7)14.2 (3.824.7)0.2 (0.00.6)
 Other extraintestinal manifestations0.6 (0.01.2)0.1 (0.00.2)0.8 (0.01.5)0.1 (0.00.2)0.2 (0.00.5)0.2 (0.00.3)
Surgery during follow-up
 Total colectomy0.8 (0.01.8)0.1 (0.00.2)0.8 (0.01.9)0.0 (0.00.0)0.4 (0.01.2)0.1 (0.00.2)
 Other intestinal resections0.1 (0.00.3)0.2 (0.10.2)−0.0 (0.00.0)0.1 (0.00.1)0.1 (0.00.3)0.1 (0.00.1)
 Perianal surgery0.5 (0.01.2)0.1 (0.00.2)0.5 (0.01.1)0.1 (0.00.2)Too few eventsToo few events
  • Note: Numbers in parentheses are 95% confidence intervals.