Table 1.

Association between methylation events and clinicopathologic features.

HeterogeneityEffect size
ComparisonStudies (N)Methylation events in casesTotal cancer cases%Methylation events in controlsTotal controls%I² (%)POR, Mantel–Haenszel random (95% CI)
p16LSIL/CIN1106636817.936260210.3000.4462.25 (1.29–3.94)
HSIL/CIN2–31014648729.9810.3023.70.2255.72 (2.92–11.2)
CC213901,14134.18781,1586.7453.050.00212.24 (6.38–23.46)
CDH1LSIL/CIN195330417.43586399.0800.5661.34 (0.52–3.47)
HSIL/CIN2–3913347128.24576169.255.80.3853.74 (1.66–8.43)
CC2142791746.5610590711.5866.510.0008.76 (3.68–20.82)
APCLSIL/CIN1152025.0082040.00NdNdNd
HSIL/CIN2–3152025.0040.00NdNdNd
CC713244129.937126027.3146.290.0832.07 (0.84–5.14)
MGMTLSIL/CIN1611434632.955023321.4600.5542.14 (3.13–4.06)
HSIL/CIN2–3614441035.1221.4656.730.0412.21 (0.70–6.96)
CC153661,14531.9719093820.2668.040.0003.34 (1.58–7.03)
hMLH1LSIL/CIN153728113.171918010.5600.8381.28 (0.76–2.14)
HSIL/CIN2–353931012.5810.5600.9331.08 (0.74–1.58)
CC9204414.54193615.264.720.3961.19 (0.49–2.88)
HIC1LSIL/CIN145815138.413915625.0000.4763.89 (0.83–18.24)
HSIL/CIN2–339924141.0825.0000.7144.81 (0.67–34.35)
CC817040442.0812233636.3153.780.0344.09 (1.6–10.42)
RASSF1LSIL/CIN15131439.0931312.2900.5022.87 (0.62–13.33)
HSIL/CIN2–366031519.0531392.1600.9768.06 (4.84–13.43)
CC274311,77524.28249972.4164.350.0007.23 (3.79–13.82)
RAR-βLSIL/CIN198831428.037957913.6467.480.0031.97 (0.62–6.24)
HSIL/CIN2–3813046627.907554413.7958.490.0181.07 (0.31–3.90)
CC1542797143.982241,12619.8973.630.0005.36 (2.71–10.58)
DAPK1LSIL/CIN11110342824.076335117.9500.4541.64 (1.04–2.57)
HSIL/CIN2–31327787931.516338316.4500.6984.98 (3.23–7.70)
CC291,0661,83658.062231,18018.9086.030.00021.74 (12.29–38.46)
FHITLSIL/CIN132016412.2082103.8100.8983.76 (2.76–6.85)
HSIL/CIN2–343224313.17113193.4500.7196.34 (2.30–17.47)
CC1532898033.47386795.6052.840.0087.42 (3.12–17.65)
CADM1LSIL/CIN194423418.80242858.420.30.4210.19 (0.45–3.12)
HSIL/CIN2–3910137726.798.4242.950.0814.01 (1.73–9.29)
CC919733958.118.4251.010.03821.73 (5.70–82.89)
MALLSIL/CIN16182098.61162257.1100.5881.91 (0.67–5.41)
HSIL/CIN2–367224928.927.117.410.3402.31 (0.22–24.76)
CC618125371.547.1162.370.02140.95 (5.07–330.94)
CCNA1LSIL/CIN151511712.8261553.8700.9832.84 (1.86–4.34)
HSIL/CIN2–355916236.423.8700.54245.99 (7.26–291.26)
CC721228773.87182786.4743.300.10271.10 (18.66–270.96)
PAX1LSIL/CIN17223087.14233147.3200.4721 (0.45–2.21)
HSIL/CIN2–3710129534.247.3257.910.0278.20 (2.27–29.70)
CC821927180.81233556.4865.400.005157.99 (24.83–1005.47)
  • Abbreviations: CC, cervical cancer; Nd, not determined.