Table 3.

Estimates from various MR methods for the association between gallstone and gallbladder cancer.

MethodOR95% LCI95% UCIP
MR estimates (SNPs = 26)
MR Egger1.621.002.630.062
Weighted median1.491.151.940.003
Inverse variance weighted1.531.162.020.003
Simple mode1.590.962.650.084
Weighted mode1.341.091.650.011
Test for directional horizontal pleiotropy test
Egger intercept (SE)−0.014 (0.046)0.774
MR estimates after removing outlier SNPs (n = 21)
MR Egger1.541.122.130.016
Weighted median1.601.222.10≤0.001
Inverse variance weighted1.501.231.83≤0.001
Simple mode1.861.073.240.040
Weighted mode1.621.242.110.002
Test for directional horizontal pleiotropy test after removing outlier SNPs (n = 21)
Radial Egger intercept (SE)−0.007 (0.028)0.814
MR-PRESSO raw estimates (SD)1.53 (0.21)0.006
MR-PRESSO outlier corrected estimate (SD)1.39 (0.14)0.003
Distortion coefficient0.303
Contamination mixture method1.571.001.990.050
  • Abbreviations: LCI, lower confidence interval; OR, odds ratio; UCI, upper confidence interval.