Table 4.

Incidence ratio of cancer in relatives of patients with pediatric cancer according to gender.

MenWomenSHAll relatives
Gender of childnSIR95% CISIR95% CIPSIR95% CI
GirlAny cancer1,0181.14a1.05–1.240.990.90–1.080.111.06a1.00–1.13
BoyAny cancer1,3421.08a1.00–1.171.06b0.98–1.150.831.07a1.02–1.13
Girl
Prostate1561.18a1.00–1.381.18a1.00–1.38
Breast1221.210.03–6.770.890.74–1.060.890.74–1.07
Lung751.160.85–1.561.220.83–1.751.19b0.93–1.49
Mouth90.720.15–2.092.07b0.76–4.501.270.58–2.41
Stomach391.240.78–1.851.59b0.91–2.591.36a0.97–1.86
Colon841.030.71–1.431.47a1.09–1.941.25a1.00–1.55
Bile duct/gallbladder171.90b0.76–3.921.590.76–2.931.71a0.99–2.73
Pancreas261.54b0.91–2.440.760.33–1.501.170.77–1.72
Pharynx71.86b0.75–3.830.000.00–6.151.600.64–3.30
Urinary tract491.25b0.90–1.690.590.24–1.221.080.80–1.43
Leukemia110.950.26–2.441.910.77–3.941.400.70–2.51
CLL151.69b0.77–3.221.910.70–4.151.77a0.99–2.93
Boy
Prostate1791.050.90–1.221.050.90–1.22
Breast1850.940.02–5.221.040.89–1.201.030.89–1.20
Lung1011.090.82–1.421.45a1.06–1.941.23a1.00–1.49
Mouth132.03a1.01–3.640.510.06–1.851.400.74–2.39
Esophagus171.79a0.95–3.061.470.40–3.761.70a0.99–2.73
Bile duct/gallbladder161.87b0.85–3.550.810.33–1.671.190.68–1.93
Pancreas371.050.60–1.701.49b0.92–2.281.26b0.89–1.74
Testis131.65b0.88–2.821.65b0.88–2.82
Kidney461.110.69–1.681.83a1.17–2.731.40a1.02–1.86
CNS tumor420.860.48–1.411.36b0.89–1.971.120.81–1.52
Hodgkin101.80b0.72–3.711.060.22–3.111.490.71–2.74
  • Note: Prostate, breast, and lung cancer and other with at least one P value <0.1 are presented.

  • Abbreviations: CLL, chronic lymphocytic leukemia; SH, sex heterogeneity.

  • aP < 0.05.

  • bP < 0.10.