Table 4.

The association between manual qualitative TDLU categories and breast cancer risk was evaluated using unconditional logistic regression models to estimate ORs and 95% CIs.

Cases/Controls nModel 1Model 2
Among women with both quantitative and qualitative data
 No type 1 lobules23/114RefRef
 Mixed lobule types93/4091.25 (0.76–2.14)1.15 (0.69–1.98)
 Predominant type 1 and no type 3 lobules61/3340.95 (0.54–1.70)0.95 (0.54–1.71)
 No type 1 lobules or mixed lobule types116/523RefRef
 Predominant type 1 and no type 3 lobules61/3340.79 (0.54–1.13)0.84 (0.58–1.22)
Women in full BBD nested case–control study with qualitative data
 No type 1 lobules41/192RefRef
 Mixed lobule types151/6401.17 (0.79–1.74)1.09 (0.74–1.65)
 Predominant type 1 and no type 3 lobules96/5420.82 (0.53–1.28)0.86 (0.56–1.35)
 No type 1 lobules or mixed lobule types192/832RefRef
 Predominant type 1 and no type 3 lobules96/5420.72 (0.54–0.96)0.80 (0.59–1.07)
  • Note: Model 1 adjusted for matching factors. Model 2 adjusted for matching factors and BBD histologic subtypes.

  • Abbreviation: BBD, benign breast disease.