Table 5.

Incidence of cancer in adult relatives of patients with pediatric cancer.

MenWomenSHAll relatives
Diagnosis of childnSIR95% CISIR95% CIPSIR95% CI
LeukemiaAny cancer7791.15a1.05–1.270.960.86–1.070.01a1.06b0.98–1.13
CNSAny cancer5421.10b0.97–1.241.12a1.00–1.270.841.11a1.02–1.21
LymphomaAny cancer3191.13b0.96–1.311.070.91–1.260.751.10a0.98–1.23
SarcomaAny cancer2901.100.94–1.280.920.77–1.090.101.010.90–1.13
OtherAny cancer4291.020.88–1.161.090.95–1.240.611.050.95–1.16
LeukemiaProstate1241.24a1.03–1.481.24a1.03–1.48
Breast980.000.00–5.890.930.76–1.140.930.75–1.13
Lung601.250.88–1.721.230.78–1.841.24b0.95–1.59
Mouth112.20a0.88–4.521.740.48–4.462.01a1.00–3.59
Stomach311.270.75–2.011.61b0.86–2.761.40a0.95–1.98
Bile duct/gallbladder112.14b0.79–4.661.000.32–2.331.410.70–2.52
Pleura43.12a0.85–8.000.000.00–13.22.57b0.70–6.57
Melanoma391.240.73–1.951.340.83–2.041.29b0.92–1.76
Leukemia81.570.51–3.661.050.22–3.061.32b0.57–2.60
CNS tumorProstate610.930.71–1.190.930.71–1.19
Breast892.400.06–13.41.26a1.01–1.551.27a1.02–1.56
Lung340.980.59–1.531.200.67–1.971.060.74–1.49
Pharynx62.73a0.89–6.371.380.03–7.682.35a0.86–5.11
Esophagus82.14b0.79–4.661.890.23–6.842.07a0.89–4.08
Colon490.780.42–1.342.01a1.41–2.781.42a1.05–1.87
Pancreas182.04a1.05–3.561.080.40–2.351.57a0.93–2.49
Kidney191.180.54–2.241.94a0.93–3.571.49b0.89–2.32
Hodgkin53.34a1.08–7.780.000.00–3.381.930.63–4.50
Leukemia81.430.29–4.172.61a0.85–6.091.99b0.86–3.92
LymphomaProstate491.190.88–1.581.190.88–1.58
Breast324.010.10–22.30.760.52–1.080.780.54–1.11
Lung190.760.35–1.441.380.66–2.530.990.60–1.55
Colon301.47b0.83–2.431.48b0.83–2.451.48a1.00–2.11
Bile duct/gallbladder74.39a1.43–10.31.050.13–3.792.30a0.92–4.74
Ovary121.86a0.96–3.241.86a0.96–3.24
Testis63.10a1.14–6.743.10a1.14–6.74
Kidney131.290.47–2.812.39a0.96–4.921.71a0.91–2.93
CNS171.670.67–3.452.17a1.04–4.001.94a1.13–3.10
Myeloma62.47b0.80–5.770.660.02–3.661.690.62–3.68
SarcomaProstate421.070.77–1.441.070.77–1.44
Breast400.000.00–14.91.000.71–1.360.990.71–1.35
Lung241.360.78–2.211.120.49–2.211.270.81–1.89
Skin161.51b0.83–2.540.290.04–1.060.990.57–1.61
OtherProstate591.050.80–1.361.050.80–1.36
Breast480.000.00–10.60.830.61–1.100.820.61–1.09
Lung391.150.69–1.81.9a1.16–2.941.44a1.03–1.98
Colon390.990.54–1.661.72a1.11–2.531.36a0.96–1.85
Skin21.260.75–2.001.380.73–2.361.31b0.89–1.86
Urinary tract261.53a0.96–2.320.790.21–2.021.34b0.87–1.96
Non-Hodgkin171.190.52–2.351.7b0.78–3.221.420.82–2.27
Hodgkin53.15a0.86–8.071.10.03–6.142.3b0.75–5.36
  • Note: Prostate, breast, and lung cancer and cancer types with at least one P value <0.1 are presented.

  • Abbreviation: SH, sex heterogeneity.

  • aP < 0.05.

  • bP < 0.1.