Table 3.

Incidence ratio of cancer in adult relatives of patients with pediatric cancer.

MenWomenSHAll relatives
Degree of relationRelatives (n)nSIR95% CISIR95% CIPSIR95% CI
1st degree2,138Any cancer1541.170.91–1.481.27a1.01–1.570.711.22a1.04–1.43
2nd degree4,990Any cancer1,0191.06b0.98–1.160.970.89–1.070.321.020.96–1.08
3rd degree6,525Any cancer1,1871.14a1.05–1.231.050.97–1.140.361.10a1.03–1.16
1st degree
Median age 37 yearsProstate161.000.57–1.631.000.57–1.63
Breast280.000.00–36.01.180.79–1.711.180.78–1.70
Lung90.570.07–2.062.32a0.93–4.771.380.63–2.62
Mouth44.18a0.86–12.222.480.06–13.823.57a0.97–9.14
Pharynx45.58a1.52–14.280.000.00–15.064.16a1.13–10.64
Pancreas30.000.00–3.413.82a0.79–11.171.610.33–4.70
Cervix82.54a1.10–5.012.54a1.10–5.01
Testis62.12b0.78–4.622.12b0.78–4.62
Melanoma151.140.37–2.661.91a0.92–3.521.56b0.87–2.57
CNS tumor90.990.21–2.911.96b0.72–4.271.480.68–2.81
2nd degree
Median age 57 yearsProstate1641.13b0.96–1.311.13b0.96–1.31
Breast1430.000.00–4.600.970.82–1.150.970.82–1.14
Lung771.140.84–1.521.080.73–1.531.120.88–1.39
Esophagus111.68b0.81–3.090.520.01–2.901.400.70–2.50
3rd degree
Median age 47 yearsProstate1551.10.93–1.291.10.93–1.29
Breast1360.990.25–7.330.940.79–1.110.950.79–1.12
Lung901.150.86–1.501.55a1.10–2.131.29a1.04–1.58
Mouth121.380.51–3.011.780.65–3.871.56b0.80–2.72
Esophagus151.440.66–2.722.27b0.83–4.951.68a0.94–2.78
Stomach501.110.74–1.591.39b0.86–2.131.210.90–1.60
Colon1110.970.68–1.341.70a1.33–2.131.36a1.12–1.64
Bile duct/gallbladder202.56a1.32–4.470.880.38–1.741.45b0.89–2.25
Pancreas371.52a0.95–2.301.080.61–1.781.31b0.92–1.80
Kidney370.860.48–1.411.76a1.10–2.671.230.87–1.70
Urinary tract651.40a1.05–1.830.800.41–1.401.23b0.95–1.56
Thyroid132.37a0.87–5.171.060.43–2.181.420.76–2.43
Non-Hodgkin381.53a0.99–2.260.890.48–1.531.230.87–1.69
Hodgkin122.77a1.27–5.251.240.25–3.612.11a1.09–3.69
  • Note: Prostate, breast, and lung cancer and other cancer with at least one P value <0.1 are presented.

  • Abbreviation: SH, sex heterogeneity.

  • aP < 0.05.

  • bP < 0.1.