Table 6.

Adult cancers in first-degree relatives of patients with pediatric cancer.

MenWomenSHAll relatives
Age at diagnosis of childnSIR95% CISIR95% CIPSIR95% CI
0–5 years of ageAny cancer651.59a1.10–2.221.270.86–1.800.561.42a1.10–1.81
>5 years of ageAny cancer890.940.66–1.301.27b0.95–1.660.351.110.89–1.36
0–5 years of age
Prostate61.140.42–2.481.140.42–2.48
Breast110.000.00–98.51.260.63–2.261.260.63–2.25
Lung50.860.02–4.773.76a1.02–9.622.24b0.73–5.23
Mouth37.82a0.95–28.276.660.17–37.17.39a1.52–21.6
Pharynx311.8a2.43–34.500.000.00–40.28.68a1.79–25.4
Liver23.910.10–21.819.270.23–51.75.50b0.67–19.9
Urinary tract32.79b0.58–8.160.000.00–11.02.130.44–6.22
Melanoma71.820.38–5.331.970.54–5.041.90b0.77–3.92
Non-Hodgkin42.190.27–7.933.500.42–12.62.70b0.73–6.91
>5 years of age
Prostate100.940.45–1.730.940.45–1.73
Breast170.000.00–56.71.140.66–1.821.130.66–1.81
Lung40.430.01–2.381.530.32–4.480.930.25–2.38
Esophagus10.000.00–8.809.88b0.25–55.11.920.05–10.7
Pancreas20.000.00–5.193.95b0.48–14.31.640.20–5.93
Cervix73.71a1.49–7.643.71a1.49–7.64
Testis42.50b0.68–6.412.50b0.68–6.41
CNS71.080.13–3.912.66a0.86–6.211.88b0.75–3.87
Hodgkin32.140.05–11.925.48b0.66–19.83.61b0.74–10.5
CLL25.46b0.66–19.720.000.00–22.33.760.46–13.6
  • Note: Prostate, breast, and lung cancer and cancer types with at least one P value <0.1 are presented.

  • Abbreviations: CLL, chronic lymphocytic leukemia; SH, sex heterogeneity.

  • aP < 0.05.

  • bP < 0.1.