Table 2.

Baseline and follow-up characteristics of participants with repeated measures.

BaselineRepeatMissing
(n = 518)(n = 518)PaBaselineRepeat
CRC status
 Cases259 (50)259 (50)
 Controls259 (50)259 (50)
Sex
 Male292 (56.4)292 (56.4)
 Female226 (43.6)226 (43.6)
Follow-up timeb, years15.6 (12.9–19.0)5.83 (2.9–9.1)00
Age at sampling, years50.0 (40.5–50.2)59.9 (51.0–60.1)<0.00100
CRP mg/L
 Cases1.26 (0.52–2.69)1.90 (0.95–4.06)<0.00100
 Controls1.14 (0.51–2.21)1.48 (0.78–3.21)<0.00100
BMI, kg/m2
 Cases25.3 (23.4–27.6)26.4 (24.3–29.1)<0.0015 (1.9)0
 Controls24.6 (22.8–27.0)26.0 (23.4–28.4)<0.0012 (0.8)0
Recreational physical activity
 Cases0.24442 (16.2)27 (10.4)
  No physical activity104 (40.2)108 (41.7)
  Low47 (18.1)52 (20.1)
  Moderate61 (23.6)58 (22.4)
  High5 (1.9)14 (5.4)
 Controls0.79147 (18.1)31 (12.0)
  No physical activity98 (37.8)106 (40.9)
  Low56 (21.6)52 (20.1)
  Moderate49 (18.9)60 (23.2)
  High9 (3.5)10 (3.9)
Alcohol intake groups, grams/day
 Cases0.33144 (17.0)2 (0.3)
  Zero6 (2.8)10 (3.9)
  Below medianc95 (44.2)97 (37.7)
  Above medianc114 (53.0)150 (58.4)
 Controls0.74041 (15.8)0
  Zero13 (6.0)17 (6.6)
  Below medianc87 (39.9)111 (42.9)
  Above medianc118 (54.1)131 (50.6)
Smoking status
 Cases0.0016 (2.3)5 (1.9)
  Nonsmoker97 (37.5)112 (43.2)
  Ex-smoker82 (31.7)103 (39.8)
  Current smoker74 (28.6)39 (15.1)
 Controls0.0036 (2.3)8 (3.1)
  Nonsmoker110 (42.5)114 (44.0)
  Ex-smoker80 (30.9)103 (39.8)
  Current smoker63 (24.3)34 (13.1)
Diabetesd
 Cases7 (2.7)16 (6.2)0.05500
 Controls2 (0.8)8 (3.1)0.05500
  • Note: N (%) or median (IQR).

  • Abbreviation: CRC, colorectal cancer.

  • aPaired Wilcoxon signed rank test within the matched case sets for continuous variables, χ2 tests for categorical variables. Cells showing missing data were not included in the statistical comparisons.

  • bFollow-up time from sample collection to CRC diagnosis.

  • cSex-specific median.

  • dObtained from self-reported question (yes/no) and/or from fasting plasma glucose levels and/or from 2-hour oral glucose tolerance test levels, according to WHO diagnostic criteria for diabetes mellitus.