Table 2.

The associations between independent variants representing each lung cancer locus and overall lung cancer risk in the DCEG Lung Cancer Study.

CytobandaLocation (bp)bSNPGeneEffect alleleReference alleleINFOEAF in caseEAF in controlOR (95% CI)P
1p31.177967507rs71658797FUBP1AT0.980.130.111.18 (1.04–1.35)1.22E-02
1q21.3154566225rs78062588cTPM3CT0.970.050.070.82 (0.68–0.98)3.11E-02
6p22.129897438rs1655931HLA-AAG0.970.140.131.15 (1.01–1.30)3.37E-02
6p22.130205174rs2517586HLA-ATC0.980.350.370.89 (0.82–0.98)1.34E-02
12p13.331051495rs2887532KDM5ATC1.000.200.210.88 (0.79–0.98)2.10E-02
15q25.178892661rs7359276IREB2TC1.000.780.741.31 (1.18–1.45)1.57E-07
15q25.179069734rs7161774IREB2TG0.960.630.660.87 (0.79–0.95)2.71E-03
  • Abbreviation: EAF, effect allele frequency.

  • aCytogenetic band.

  • bSNP position, build 37.

  • cSNPs (or loci) that were first identified as potential lung cancer susceptibility loci in this study.