Table 1.

Frequency and IRRa by sex (males:females) in SEER Site Recode ICD-O-3/WHO 2008 Sites, 2001-2016, National Program of Cancer Registries and Surveillance, Epidemiology, and End Results SEER*Stat Database: NPCR and SEER Incidence – U.S. Cancer Statistics Public Use Research Database, November 2018 Submission (2001–2016).

Cancer siteMaleFemale% of all tumorsMale-to-female IRR (95% CI)P
All sites6,423,0737,858,728100.000.958 (0.9570.959)<0.001
Oral cavity and pharynx325,572133,5123.212.737 (2.7192.755)<0.001
  Lip 19,6976,9540.193.509 (3.413–3.608)<0.001
  Tongue96,45738,1670.942.797 (2.764–2.831)<0.001
  Salivary gland27,45020,4120.341.573 (1.544–1.602)<0.001
  Floor of mouth17,6497,4420.182.660 (2.588–2.734)<0.001
  Gum and other mouth33,40626,6420.421.478 (1.454–1.502)<0.001
  Nasopharynx16,5286,9230.162.569 (2.497–2.643)<0.001
  Tonsil71,37615,2150.615.077 (4.987–5.167)<0.001
  Oropharynx15,0814,5010.143.746 (3.622–3.875)<0.001
  Hypopharynx21,0685,0710.184.750 (4.605–4.900)<0.001
  Other oral cavity and pharynx6,8602,1850.063.577 (3.406–3.757)<0.001
Digestive system1,788,5381,480,61022.891.454 (1.451–1.457)<0.001
  Esophagus154,33540,5761.364.573 (4.523–4.624)<0.001
  Stomach170,160106,3781.941.948 (1.933–1.963)<0.001
  Small intestine44,55041,0420.601.270 (1.253–1.287)<0.001
  Colon and rectum946,324893,24112.881.287 (1.284–1.291)<0.001
   Colon-excluding rectum637,241666,2919.131.184 (1.180–1.188)<0.001
    Cecum124,940159,8181.991.002 (0.995–1.010)0.60
    Appendix17,85521,6050.280.900 (0.883–0.919)<0.001
    Ascending colon112,188136,5241.741.054 (1.046–1.063)<0.001
    Hepatic flexure30,73731,5540.441.248 (1.228–1.268)<0.001
    Transverse colon53,38558,8280.791.144 (1.131–1.158)<0.001
    Splenic flexure21,48318,9130.281.392 (1.365–1.420)<0.001
    Descending colon40,21434,7930.531.387 (1.367–1.407)<0.001
    Sigmoid colon199,590167,2022.571.414 (1.405–1.424)<0.001
    Large intestine, NOS36,84937,0540.521.253 (1.234–1.271)<0.001
   Rectum and rectosigmoid junction309,083226,9503.751.585 (1.576–1.594)<0.001
    Rectosigmoid junction79,22661,9890.991.500 (1.484–1.516)<0.001
    Rectum229,857164,9612.761.617 (1.607–1.627)<0.001
  Anus, anal canal, and anorectum26,63945,2510.500.683 (0.672–0.693)<0.001
  Liver and intrahepatic bile duct193,30173,7361.872.973 (2.948–2.999)<0.001
   Liver179,42559,9811.683.381 (3.349–3.412)<0.001
   Intrahepatic bile duct13,87613,7550.191.199 (1.171–1.229)<0.001
  Gallbladder13,58431,9070.320.543 (0.532–0.554)<0.001
  Other biliary30,66626,4440.401.445 (1.421–1.469)<0.001
  Pancreas192,135185,7112.651.260 (1.252–1.269)<0.001
  Retroperitoneum7,4287,9980.111.036 (1.003–1.070)0.03
  Peritoneum, omentum, and mesentery1,66320,3770.150.098 (0.093–0.103)<0.001
  Other digestive organs7,7537,9490.111.200 (1.163–1.239)<0.001
Breast23,5082,851,89220.130.010 (0.009–0.010)<0.001
Respiratory system1,301,9011,045,14416.431.505 (1.501–1.509)<0.001
  Nose, nasal cavity, and middle ear16,79311,2130.201.730 (1.688–1.772)<0.001
  Larynx126,41131,8261.114.567 (4.511–4.624)<0.001
  Lung and bronchus1,153,272999,50915.071.402 (1.398–1.406)<0.001
  Pleura5883900.011.876 (1.645–2.142)<0.001
  Trachea, mediastinum, and other respiratory organs4,8372,2060.052.366 (2.248–2.491)<0.001
Bones and joints21,86817,2560.271.318 (1.292–1.345)<0.001
Soft tissue, including heart71,12458,3940.911.367 (1.352–1.383)<0.001
Skin, excluding basal and squamous481,029377,9546.011.432 (1.426–1.438)<0.001
  Melanoma of the skin445,071351,6015.581.414 (1.408–1.420)<0.001
  Other nonepithelial skin35,95826,3530.441.684 (1.657–1.711)<0.001
Urinary system1,011,526452,23610.252.724 (2.714–2.734)<0.001
  Urinary bladder610,248202,6265.693.854 (3.835–3.874)<0.001
  Kidney and renal pelvis386,667239,6134.391.843 (1.834–1.853)<0.001
  Ureter9,9296,9530.121.853 (1.796–1.912)<0.001
  Other urinary organs4,6823,0440.051.965 (1.876–2.059)<0.001
Eye and orbit14,91812,1090.191.380 (1.347–1.414)<0.001
Brain and other nervous system158,403126,9712.001.368 (1.357–1.378)<0.001
  Brain149,601117,2201.871.404 (1.393–1.415)<0.001
  Cranial nerves and other nervous system8,8029,7510.130.956 (0.929–0.985)0.003
Endocrine system138,181417,6463.890.343 (0.341–0.345)<0.001
  Thyroid121,823403,0563.680.313 (0.311–0.315)<0.001
  Other endocrine, including thymus16,35814,5900.221.199 (1.172–1.226)<0.001
Lymphoma481,556412,3336.261.366 (1.361–1.372)<0.001
  Hodgkin lymphoma66,93355,0680.851.257 (1.243–1.272)<0.001
   Nodal65,23653,5830.831.258 (1.244–1.273)<0.001
   Extranodal1,6971,4850.021.228 (1.144–1.319)<0.001
  Non-Hodgkin lymphoma414,623357,2655.401.386 (1.379–1.392)<0.001
   Nodal283,299238,7723.661.414 (1.406–1.422)<0.001
   Extranodal131,324118,4931.751.329 (1.319–1.340)<0.001
Myeloma131,949110,0111.691.449 (1.437–1.461)<0.001
Leukemia274,944199,3593.321.606 (1.596–1.615)<0.001
  Lymphocytic leukemia147,27897,3781.711.742 (1.728–1.757)<0.001
  Acute lymphocytic leukemia38,17728,8360.471.322 (1.302–1.342)<0.001
  Chronic lymphocytic leukemia96,95064,2441.131.869 (1.850–1.888)<0.001
  Other lymphocytic leukemia12,1514,2980.123.259 (3.146–3.377)<0.001
  Myeloid and monocytic leukemia118,81894,6721.491.474 (1.461–1.486)<0.001
  Acute myeloid leukemia73,46060,7540.941.422 (1.406–1.437)<0.001
  Acute monocytic leukemia4,8344,0510.061.372 (1.314–1.431)<0.001
  Chronic myeloid leukemia37,34027,3830.451.596 (1.571–1.622)<0.001
  Other myeloid/monocytic leukemia3,1842,4840.041.563 (1.481–1.649)<0.001
  Other leukemia8,8487,3090.111.493 (1.446–1.540)<0.001
  Other acute leukemia4,0883,1990.051.579 (1.507–1.656)<0.001
  Aleukemic, subleukemic, and NOS4,7604,1100.061.424 (1.365–1.486)<0.001
Mesothelioma26,8408,3140.854.112 (4.011–4.216)<0.001
Kaposi sarcoma14,9561,8980.839.751 (9.287–10.242)<0.001
  • Note: Bold text indicates major site grouping.

  • Abbreviations: CI, confidence interval; ICD-O-3/WHO 2008, International Classification of Diseases for Oncology, 3rd Edition, 2000. World Health Organization, Geneva, Switzerland; NOS, not otherwise specified; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program.

  • aRates are per 100,000 and age-adjusted to the 2000 U.S. standard population.