Table 1.

Baseline characteristics of participants, N (%)a or median (IQR).

AllCRP <1 mg/LCRP 1–3 mg/LCRP >3 mg/LPbMissingc
All participants2,020793 (39.3)716 (35.4)511 (25.3)0
CRC status0.164
 Cases1,010 (50)385 (48.5)351 (49.0)274 (53.6)0
 Controls1,010 (50)408 (51.5)365 (51.0)237 (46.4)0
Sex0.249
 Male1,050 (52.0)427 (53.8)372 (52.0)251 (49.1)0
 Female970 (48.0)366 (46.2)344 (48.0)260 (50.9)
Age at baseline56.3 (49.9–60.0)50.3 (49.8–60.0)59.3 (50.0–60.0)59.8 (50.0–60.1)<0.0010
Age at diagnosis of cases66.4 (60.5–72.6)65.3 (57.4–71.2)67.6 (61.7–73.6)66.8 (61.9–73.0)<0.0010
Follow-up time of casesd12.3 (7.5–16.6)12.3 (7.7–16.5)12.7 (7.9–17.9)11.7 (6.4–15.6)0.0350
BMI, kg/m225.7 (23.5–28.4)24.4 (22.6–26.4)26.2 (24.0–28.5)27.6 (24.9–30.5)<0.00120 (1.0)
Recreational physical activity0.109161 (8.0)
 No physical activity793 (42.7)298 (41.2)277 (41.8)218 (46.1)
 Low472 (25.4)181 (25.0)183 (27.6)108 (22.8)
 Moderate504 (27.1)217 (30.0)167 (25.2)120 (25.4)
 High90 (4.8)28 (3.9)35 (5.3)27 (5.7)
Alcohol intake groups, gram/day0.589298 (14.8)
 Zero142 (8.2)49 (7.5)48 (7.7)45 (10.1)
 Below mediane725 (42.1)279 (42.7)263 (42.1)183 (41.1)
 Above mediane855 (49.7)325 (49.8)313 (50.2)217 (48.8)
Smoking status0.00143 (2.1)
 Nonsmoker832 (42.1)358 (46.0)300 (43.2)174 (34.5)
 Ex-smoker680 (34.4)255 (32.7)237 (34.1)188 (37.3)
 Current smoker465 (23.5)166 (21.3)157 (22.6)142 (28.2)
Diabetesf122 (6.0)27 (3.4)47 (6.6)48 (9.4)<0.0010
Education level<0.00143 (2.1)
 No secondary1,327 (67.1)478 (61.2)498 (71.3)351 (70.5)
 Secondary314 (15.9)144 (18.4)99 (14.2)71 (14.3)
 Post-secondary336 (17.0)159 (20.4)101 (14.5)76 (15.3)
  • Abbreviation: CRC, colorectal cancer.

  • aPercent of participants calculated within CRP categories, except for “all participants.”

  • bχ2 tests for differences between CRP groups (% of participants with existing data) for categorical variables, Kruskal–Wallis tests for differences between CRP groups for continuous variables.

  • cN and % of participants in total (N = 2,020). Missing category not included in the statistical comparisons.

  • dFollow-up time from baseline sample collection to CRC diagnosis.

  • eSex-specific median.

  • fObtained from self-reported question (yes/no) or from fasting plasma glucose levels or from 2-hour oral glucose tolerance test levels, according to WHO diagnostic criteria for diabetes mellitus.