Table 1.

The associations between independent variants representing each lung cancer locus and overall lung cancer risk in the OncoArray dataset.

CytobandaLocation (bp)bSNPGeneEffect alleleReference alleleINFOEAF in caseEAF in controlOR (95% CI)P
1p31.177967507rs71658797FUBP1AT1.000.110.101.14 (1.08–1.20)1.04E-06
1q21.3154566225rs78062588cTPM3CT0.950.060.070.87 (0.81–0.92)1.55E-05
6p22.129897438rs1655931HLA-AAG0.960.170.151.15 (1.10–1.20)3.79E-10
6p22.130205174rs2517586HLA-ATC0.990.330.350.92 (0.89–0.95)8.84E-07
12p13.331051495rs2887532KDM5ATC1.000.170.180.93 (0.89–0.97)3.90E-04
15q25.178892661rs7359276IREB2TC1.000.800.761.27 (1.22–1.32)9.74E-35
15q25.179069734rs7161774IREB2TG0.960.570.600.85 (0.82–0.88)9.39E-23
  • Abbreviation: EAF, effect allele frequency.

  • aCytogenetic band.

  • bSNP position, build 37.

  • cSNPs (or loci) that were first identified as potential lung cancer susceptibility loci in this study.