Table 2.

Clinical performance of dual-stained cytology, Pap cytology, and HPV16/18 typing for detection of CIN2+ or CIN3+.

Dual-stained cytologyPap cytologyHPV16/18 typing
Positive, n/NEstimate (95% CI)Positive, n/NEstimate (95% CI)Positive, n/NEstimate (95% CI)PaP'b
Detection of CIN2+ (N = 126)
 Sensitivity80/12663.49% (54.4%–71.9%)78/12661.90% (52.8%–70.4%)78/12661.90% (52.8%–70.4%)0.8320.897
 Specificity614/72085.28% (82.5%–87.8%)576/72080.00% (76.9%–82.9%)521/72072.36% (68.9%–75.6%)<0.001<0.001
 PPV80/18643.01% (35.8%–50.5%)78/22235.14% (28.9%–41.8%)78/27728.16% (22.9%–33.8%)0.001<0.001
 NPV614/66093.03% (90.8%–94.9%)576/62492.31% (89.9%–94.3%)521/56991.56% (89.0%–93.8%)<0.001<0.001
Detection of CIN3+ (N = 116)
 Sensitivity75/11664.66% (55.2%–73.3%)73/11662.93% (53.5%–71.7%)73/11662.93% (53.5%–71.7%)0.8240.892
 Specificity619/73084.79% (82.0%–87.3%)581/73079.59% (76.5%–82.5%)526/73072.05% (68.6%–75.3%)<0.001<0.001
 PPV75/18640.32% (33.2%–47.7%)73/22232.88% (26.7%–39.5%)73/27726.35% (21.3%–32.0%)0.002<0.001
 NPV619/66093.79% (91.7%–95.5%)581/62493.11% (90.8%–95.0%)526/56992.44% (90.0%–94.5%)<0.001<0.001
  • Abbreviation: CI, confidence interval.

  • aP value indicates the comparison between dual-stained cytology and Pap cytology.

  • bP' value indicates the comparison between dual-stained cytology and HPV16/18 typing.