Table 2.

Means, geometric means (GM), or proportions (%) and 95% confidence intervals of covariates by NMR and data source.

Slow metabolizersNormal/fast metabolizersP
PATH Wave 1
N = 4,642,172N = 13,941,182
Age (years), mean40.23 (38.10–42.37)45.47 (43.97–46.97)0.0002
Female sex, %40.79 (32.99–49.09)59.51 (55.20–63.68)<0.0001
Body mass index, mean27.82 (26.94–28.70)27.14 (26.54–27.75)0.1864
Years smoking, mean21.92 (19.51–24.34)26.35 (25.16–27.55)0.0013
Smokes menthol cigarettes, %27.13 (21.99–32.97)30.10 (24.54–36.32)0.4344
Urinary creatinine, GM1.11 (1.00–1.22)0.88 (0.82–0.94)0.0004
HSI, mean3.02 (2.80–3.23)3.27 (3.11–3.44)0.0510
HSIa, mean2.95 (2.73–3.17)3.28 (3.07–3.48)0.0178
WISDM PDM8, mean3.30 (3.16–3.43)3.44 (3.35–3.54)0.0778
WISDM PDM8a, mean3.35 (3.22–3.48)3.43 (3.33–3.53)0.2884
Baseline data from RCT
N = 148N = 591
Age (years), mean43.41 (41.27–45.54)45.36 (44.17–46.54)0.1392
Female sex, %33.78 (26.15–41.42)47.88 (43.85–51.92)0.0020
Body mass index, mean29.71 (28.69–30.72)28.50 (27.97–29.01)0.0376
Years smoking, mean26.20 (24.06–28.34)28.23 (27.04–29.41)0.1245
Smokes menthol cigarettes, %30.41 (22.98–37.84)23.35 (19.93–26.77)0.0754
Urinary creatinine, GM1.00 (0.90–1.12)0.95 (0.90–1.01)0.4085
Expired CO, mean20.08 (18.64–21.51)20.93 (20.12–21.73)0.3431
HSI, mean3.42 (3.19–3.65)3.41 (3.29–3.52)0.9315
HSIa, mean3.34 (3.10–3.57)3.35 (3.21–3.48)0.9447
WISDM PDM16, mean4.26 (4.04–4.48)4.23 (4.12–4.35)0.8415
WISDM PDM16a, mean4.27 (4.04–4.50)4.22 (4.08–4.35)0.6739
  • Note: PATH data are weighted; parentheses include 95% confidence intervals; bold values indicate statistical significance at P < 0.05.

  • Abbreviation: GM, geometric mean.

  • aEstimates adjusted for age, sex, body mass index, duration regular smoking, and menthol use.