Table 2.

Overall and stratified associations for genetically predicted PUFAs and colorectal cancer risk using individual-level data in the GECCO.

Omega-6 PUFAsOmega-3 PUFAs
LAAAALAEPADPADHA
SubgroupCases/controlsORa (95% CI)PORa (95% CI)PORa (95% CI)PORa (95% CI)PORa (95% CI)PORa (95% CI)P
Overall11,016/13,7320.96 (0.93–0.98)5.2 × 10−41.06 (1.03–1.08)3.3 × 10−50.95 (0.92–0.97)5.4 × 10−51.04 (1.01–1.07)2.5 × 10−31.03 (1.01–1.06)1.2 × 10−21.01 (0.98–1.03)0.53
Sex
 Female5,810/7,3270.94 (0.91–0.97)4.2 × 10−41.07 (1.03–1.10)3.2 × 10−40.94 (0.90–0.97)2.3 × 10−41.06 (1.02–1.10)1.1 × 10−31.05 (1.01–1.08)1.1 × 10−21.01 (0.98–1.05)0.52
 Male5,206/6,4050.98 (0.94–1.02)0.261.04 (1.00–1.08)0.040.97 (0.93–1.00)0.071.02 (0.98–1.06)0.391.02 (0.98–1.06)0.391.00 (0.97–1.04)0.87
Pinteractionb0.150.400.290.140.340.73
Age
 <65 years5,770/7,0960.98 (0.95–1.02)0.361.03 (0.99–1.07)0.080.97 (0.94–1.01)0.111.03 (0.99–1.07)0.091.02 (0.98–1.05)0.370.99 (0.95–1.02)0.47
 ≥65 years5,246/6,6360.93 (0.89–0.96)5.4 × 10−51.08 (1.04–1.12)2.7 × 10−50.92 (0.89–0.96)2.7 × 10−51.05 (1.01–1.09)1.0 × 10−21.05 (1.01–1.09)5.7 × 10−31.03 (0.99–1.07)0.12
Pinteractionb1.5 × 10−20.060.040.470.140.10
Smoking
 Ever6,090/7,5260.97 (0.93–1.00)0.061.05 (1.01–1.09)5.7 × 10−30.95 (0.92–0.99)8.7 × 10−31.04 (1.00–1.08)3.2 × 10−21.03 (0.99–1.06)0.141.01 (0.97–1.05)0.57
 Never4,745/6,1210.94 (0.91–0.98)3.4 × 10−31.06 (1.02–1.10)3.4 × 10−30.94 (0.91–0.98)3.3 × 10−31.04 (1.00–1.08)3.6 × 10−21.04 (1.00–1.08)3.2 × 10−21.00 (0.96–1.04)0.88
Pinteractionb0.330.710.630.830.670.55
Aspirin/NSAID use
 Yes3,058/5,0610.98 (0.94–1.03)0.401.02 (0.98–1.07)0.340.98 (0.94–1.03)0.401.00 (0.95–1.04)0.881.00 (0.96–1.05)0.921.03 (0.98–1.08)0.22
 No6,919/7,6720.94 (0.91–0.97)2.3 × 10−41.08 (1.04–1.11)8.3 × 10−60.93 (0.90–0.96)9.7 × 10−61.07 (1.03–1.10)1.7 × 10−41.05 (1.02–1.09)2.4 × 10−31.01 (0.97–1.04)0.72
Pinteractionb0.110.050.041.4 × 10−20.060.45
Cancer site
 Rectal2,849/13,7320.96 (0.92–1.00)0.061.06 (1.01–1.10)9.7 × 10−30.95 (0.91–0.99)0.011.06 (1.02–1.11)4.4 × 10−31.04 (1.00–1.09)4.7 × 10−20.99 (0.95–1.04)0.72
 Colon7,907/13,7320.96 (0.93–0.98)1.9 × 10−31.05 (1.02–1.08)6.0 × 10−40.95 (0.93–0.98)7.8 × 10−41.03 (1.00–1.06)4.0 × 10−21.03 (0.99–1.06)0.071.01 (0.98–1.04)0.39
 Proximal colon4,319/13,7320.95 (0.92–0.99)6.2 × 10−31.05 (1.01–1.09)5.3 × 10−30.95 (0.92–0.99)5.6 × 10−31.03 (0.99–1.07)0.061.03 (0.99–1.07)0.071.00 (0.97–1.04)0.80
 Distal colon3,439/13,7320.95 (0.92–0.99)1.5 × 10−21.06 (1.02–1.10)3.3 × 10−30.95 (0.91–0.98)4.5 × 10−31.04 (0.99–1.08)0.71.03 (0.98–1.07)0.161.02 (0.98–1.06)0.35
Phomogeneity0.950.960.990.750.990.79
Body mass index
 ≤18.5 kg/m296/1210.89 (0.65–1.21)0.451.10 (0.81–1.50)0.540.88 (0.65–1.21)0.461.20 (0.85–1.69)0.301.10 (0.82–1.49)0.520.96 (0.72–1.30)0.81
 18.5–24.93,426/4,8420.95 (0.90–0.99)1.4 × 10−21.06 (1.01–1.10)1.4 × 10−20.94 (0.90–0.99)0.011.05 (1.00–1.11)3.6 × 10−21.02 (0.98–1.07)0.281.03 (0.98–1.07)0.25
 25.0–30.04,114/5,2110.96 (0.93–1.01)0.091.05 (1.01–1.10)1.4 × 10−20.95 (0.91–0.99)0.031.04 (0.99–1.09)0.091.03 (0.99–1.07)0.181.01 (0.97–1.05)0.67
 >30.02,243/2,4430.95 (0.90–1.01)0.111.06 (1.00–1.13)0.040.94 (0.88–0.99)0.041.04 (0.98–1.11)0.221.05 (0.98–1.11)0.141.01 (0.96–1.07)0.66
Pinteractionb0.880.980.940.870.850.88
  • aAll models adjusted for age, sex, study, and top principal components for European ancestry. ORs represent associations per 1 SD increase in PUFA-specific wGS, which corresponds to the following increase in percent of total plasma fatty acids: 1.18% increase in LA; 1.11% increase in AA; 0.01% increase in ALA; 0.06% increase in EPA; 0.06% increase in DPA; and 0.08% increase in DHA.

  • bPinteraction calculated using nested models for the multiplicative interaction term via a likelihood ratio test with a χ2 distribution with 1 degree of freedom.