Table 2.

Comparison of the incidence of leukemia by dengue virus infection status.

Dengue cohortNon-dengue cohort
CancerNo. of eventsIncidence rate (per 100,000 person-years)No. of eventsIncidence rate (per 100,000 person-years)Crude HR (95% CI)PAdjusted HRa (95% CI)PAdjusted SHRa (95% CI)P
All leukemia1917.20437.852.19 (1.28–3.76)0.0042.03 (1.16–3.53)0.0132.06 (1.21–3.49)0.008
 Lymphocytic leukemiab65.43152.741.98 (0.77–5.11)0.1562.04 (0.77–5.40)0.1502.06 (0.78–5.43)0.144
 Myeloid leukemia109.05285.111.77 (0.86–3.64)0.1221.62 (0.77–3.42)0.2031.65 (0.83–3.30)0.156
  AML65.43193.471.56 (0.63–3.92)0.3401.25 (0.49–3.20)0.6381.28 (0.53–3.09)0.589
  CML32.7291.641.65 (0.45–6.09)0.4532.04 (0.52–8.05)0.3102.06 (0.58–7.38)0.266
  • Abbreviations: AML, acute myeloid leukemia; CML, chronic myeloid leukemia; No., number; SHR, subdistribution HR.

  • aAdjusted for age, sex, area of residence, urbanization level, monthly income level, and comorbidities.

  • bLymphocytic leukemia was not further classified into acute lymphoblastic leukemia and chronic lymphocytic leukemia because results less than three individuals were not allowed to be exported under the regulations of the HWDC in Taiwan.