Table 1.

Baseline characteristics of study subjects according to anti–H. pylori IgG titer and severity of atrophic gastritis (JPHC Cohort II; n = 19,106).

Anti–H. pylori IgG titerSeverity of atrophic gastritis
Number of subjectsLow-negative ≤3 U/mLHigh-negative >3 and <10 U/mLPositive ≥10 U/mLNoneMildModerateSevere
n (%)n (%)n (%)n (%)n (%)n (%)n (%)n (%)
Total19,106 (100.0)4,244 (22.2)1,784 (9.3)13,078 (68.5)5,429 (28.4)5,638 (29.5)7,440 (38.9)599 (3.1)
Men6,9341,339 (19.3)669 (9.7)4,926 (71.0)1,748 (25.2)2,204 (31.8)2,722 (39.3)260 (3.7)
Women12,1722,905 (23.9)1,115 (9.1)8,152 (67.0)3,681 (30.2)3,434 (28.2)4,718 (38.8)339 (2.8)
Age (years ± SD)56.7 (±8.3)55.2 (±8.7)57.5 (±8.0)57.0 (±8.1)55.7 (±8.4)56.6 (±8.0)57.4 (±8.0)60.9 (±6.7)
Smoking status
 Never and former15,634 (81.8)3,585 (84.5)1,372 (76.9)10,677 (81.6)9,074 (82.0)2,344 (85.7)2,648 (82.0)1,568 (75.6)
 Current3,472 (18.2)659 (15.5)412 (23.1)2,401 (18.4)1,993 (18.0)390 (14.3)583 (18.0)506 (24.4)
Men
Never and former3,976 (57.3)800 (18.9)318 (17.8)2,858 (21.9)2,281 (57.7)521 (62.0)663 (57.3)511 (51.9)
Current2,958 (42.7)539 (12.7)351 (19.7)2,068 (15.8)1,671 (42.3)319 (38.0)494 (42.7)474 (48.1)
Women
Never and former11,658 (57.3)2,785 (65.6)1,054 (59.1)7,819 (59.8)6,793 (95.5)1,823 (96.3)1,985 (95.7)1,057 (97.1)
Current514 (42.7)120 (2.8)61 (3.4)333 (2.5)322 (4.5)71 (3.7)89 (4.3)32 (2.9)
Family history (parents or siblings)
 No17,836 (93.4)4,003 (94.3)1,674 (93.8)12,159 (93.0)10,390 (93.9)2,554 (93.4)2,994 (92.7)1,898 (91.5)
 Yes1,270 (6.6)241 (5.7)110 (6.2)919 (7.0)677 (6.1)180 (6.6)237 (7.3)176 (8.5)
Consumption of highly salted food (fish roe, fish gut)
 No8,460 (44.3)2,029 (47.8)832 (46.6)5,599 (42.8)5,072 (45.8)1,182 (43.2)1,372 (42.5)834 (40.2)
 Yes10,646 (55.7)2,215 (52.2)952 (53.4)7,479 (57.2)5,995 (54.2)1,552 (56.8)1,859 (57.5)1240 (59.8)
Atrophic gastritis
 Absent11,067 (57.9)4,020 (94.7)1,409 (79.0)5,638 (43.1)
 Mild2,734 (14.3)11 (0.3)53 (3.0)2,670 (20.4)
 Moderate3,231 (16.9)92 (2.2)146 (8.2)2,994 (22.9)
 Severe2,074 (10.9)121 (2.9)176 (9.9)1,777 (13.6)
Atrophic gastritis
 Low-negative ≤3 U/mL4,244 (22.2)4,020 (36.3)11 (0.4)92 (2.9)121 (5.8)
 High-negative >3 and <10 U/mL1,784 (9.3)1,409 (12.7)53 (1.9)146 (4.5)176 (8.5)
 Positive ≥10 U/mL13,078 (68.4)5,638 (51.0)2,670 (97.7)2,993 (92.6)1,777 (85.7)
  • Note: Atrophic gastritis: Negative (PG I >70 ng/mL or PG I/II >3.0), positive (PG I ≤70 ng/mL and PG I/II ≤3.0), mild (PG I ≤70 ng/mL and PG I/II ≤3.0 and not moderate/severe), moderate (PG I ≤50 ng/mL and PG I/II ≤3.0 and not severe), severe (PG I ≤30 ng/mL and PG I/II ≤2.0). Sex-specific values are in italic.