Table 2.

Stratification of individuals according to polygenic risk and family history of colorectal cancera.

Risk groupRisk categoryDescriptionRRPP (%)
Very low1Lowest quintile for polygenic risk and no CRC in first-degree relatives0.4720
Low2Second lowest quintile for polygenic risk and no CRC in first-degree relatives0.7223
Average3Lowest quintile for polygenic risk and at least one CRC in first-degree relative OR middle quintile for polygenic risk and no CRC in first-degree relatives0.9318
4Second highest quintile for polygenic risk and no CRC in first-degree relatives1.1414
High5Second lowest quintile for polygenic risk and at least one CRC in first-degree relatives1.453
6Middle quintile for polygenic risk and at least one CRC in first-degree relative OR highest quintile for polygenic risk and no CRC in first-degree relatives1.7018
Very high7Second highest quintile for polygenic risk and at least one CRC in first-degree relatives2.312
8Highest quintile for polygenic risk and at least one CRC in first-degree relatives3.402
  • Abbreviations: CRC, colorectal cancer; PP, population percentage; RR, relative risk, risk of colorectal cancer in category compared with the average risk of colorectal cancer.

  • aStratification based on Jenkins and colleagues (14).