Table 1.

Female probands' reports (N = 1,716) of female first-degree family history of breast and other cancersa compared with female relatives' reports (N = 3,136) of personal cancer historyb, Northern California Breast Cancer Family Registry

Positive relativec reportNegative relativec report
Positive proband reportNegative proband reportPositive proband reportNegative proband reportSensitivity % (95% CI)dSpecificity % (95% CI)dOverall agreemente
Breast cancerf
Type of relative2792162,83093.0 (89.5–95.4)99.8 (99.5–99.9)0.95
 Mother613032295.3 (86.5–98.5)1000.97
 Sister2181862,50892.4 (88.2–95.1)99.8 (99.5–99.9)0.94
Other cancersg11976232,918
 Ovarianh174i6l3,10981.0 (58.8–92.7)99.8 (99.6–99.9)0.77
 Skinh2124i9m3,08246.4 (32.5–60.8)99.7 (99.4–99.8)0.55
 Cervicalh1823j2m3,09342.5 (28.3–58.0)99.9 (99.7–100)0.59
 Colorectalh113i2m3,12078.6 (50.6–92.9)99.9 (99.7–100)0.81
 Uterineh1518k6n3,09745.5 (29.6–62.3)99.8 (99.6–99.9)0.55
 Lungh83i03,12572.7 (41.4–91.0)1000.84
  • aProbands could report multiple cancers for each relative in the family history questionnaire.

  • bRelatives could report multiple cancers in the personal cancer history section of the risk factor questionnaire.

  • cFull and half-sisters and mothers.

  • dCalculated using GEE to account for multiple members in one family.

  • eKappa statistic (0.2 = slight, 0.21–0.4 = fair, 0.41-0.6 = moderate, 0.61–0.8 = substantial, 0.81–1.0 = almost perfect).

  • fRelatives with breast cancer only or with multiple primary cancers, including breast cancer.

  • gRelatives with at least one primary non-breast cancer.

  • hRelatives with cancer(s) at the site specified only or those with multiple primary cancers, including one at the site specified.

  • iRelatives reported 4 ovarian, 24 skin, 3 colorectal, and 3 lung cancers; probands reported no cancer.

  • jRelatives reported 23 cervical cancers; probands reported 1 breast, 1 ovarian, and 4 uterine cancers, and 17 reported no cancer.

  • kRelatives reported 18 uterine cancers; probands reported 2 ovarian cancers, and 16 reported no cancer.

  • lProbands reported 6 ovarian cancers; relatives reported 2 uterine and 1 cervical cancer, and 3 relatives reported no cancer.

  • mProbands reported 9 skin cancers, 2 cervical, and 2 colorectal cancers; relatives reported no cancer.

  • nProbands reported 6 uterine cancers; relatives reported 4 cervical cancers, and 2 relatives reported no cancer.