Table 3.

TN prevalence among BRCA1 mutation carriers in Latina women

Recruitment strategyPopulation includedCountryMutation assessment technologySample sizeNo. of BRCA1-positive patients (%)No. of TNBC among BRCA1-positive patients (%)Reference
Selected patientsNHW and Latina womenU.S.BRCA testing8031 (38.7)23 (74)(33)
LatinasColombia25-gene hereditary cancer panel (myRisk, Myriad)856 (7)6 (100)(79)
Latinas <50 yearsMexicoHISPANEL assaya190 (only TNBC patients)43 (22.6)43 (100)(83)
Unselected patientsHispanic and LatinasMexicoHISPANEL assaya9611 (11.4)9 (81.8)(80)
Spain and PeruTargeted next-generation sequencing (of BRCA1, BRCA2, PALB2, BARD1, RAD50, RAD51C, and RAD51D)105 (only TNBC patients)13 (12.4)13 (100)(81)
  • Abbreviations: NHW, non-Hispanic white women; No., number; TNBC, triple-negative breast cancer; U.S., United States.

  • aHISPANEL assay: 114 BRCA mutation panel based on data from Hispanics from the United States, Spain, and South America.