Table 1.

Frequency of somatic mutations and alterations in NSCLC

GeneAlteration typeFrequency in NSCLC
EGFRMutation10%–35%
KRASMutation15%–25%
FGFR1Amplification20%
PTENMutation4%–8%
DDR2Mutation∼4%
ALKRearrangement3%–7%
HER2Mutation2%–4%
METAmplification2%–4%
BRAFMutation1%–3%
PIK3CAMutation1%–3%
AKT1Mutation1%
MEK1Mutation1%
NRASMutation1%
RETRearrangement1%
ROS1Rearrangement1%