Table 3.

Fully adjusted associations of aMED and mMED (including and excluding alcohol) with bladder cancer risk in the Netherlands Cohort Study

Bladder cancer
AllNoninvasiveInvasive
PYsubcohortCasesHR (95% CI)aAICCasesHR (95% CI)aAICCasesHR (95% CI)aAIC
aMEDr
 0–324,3027901.003981.003921.00
 4–528,0057960.95 (0.82–1.09)4180.98 (0.83–1.17)3780.91 (0.76–1.08)
 6–811,0552981.00 (0.83–1.21)28,5401561.02 (0.81–1.28)14,7111420.98 (0.77–1.24)13,840
Ptrend0.9310.8980.783
 Continuous, per 2 pts63,3621,8841.00 (0.92–1.09)28,5409721.01 (0.92–1.12)14,7099120.99 (0.89–1.09)13,840
aMEDb
 0–320,1076461.003161.003301.00
 4–528,0387950.90 (0.78–1.05)4220.98 (0.81–1.17)3730.84 (0.70–1.00)
 6–915,2174430.99 (0.83–1.18)28,5442341.05 (0.85–1.29)14,7122090.93 (0.75–1.16)13,840
Ptrend0.5910.8500.279
 Continuous, per 2 pts63,3621,8841.00 (0.93–1.08)28,5469721.03 (0.94–1.14)14,7109120.97 (0.88–1.07)13,843
mMEDr
 0–322,7217251.003601.003651.00
 4–530,3848820.98 (0.85–1.13)4651.04 (0.87–1.23)4170.92 (0.77–1.10)
 6–810,2562770.90 (0.74–1.09)28,5391470.94 (0.74–1.19)14,7101300.85 (0.67–1.09)13,839
Ptrend0.2730.6450.182
 Continuous, per 2 pts63,3621,8840.97 (0.89–1.06)28,5399721.00 (0.90–1.11)14,7099120.95 (0.85–1.06)13,839
mMEDb
 0–317,6185311.002651.002661.00
 4–530,9538880.91 (0.78–1.06)4620.95 (0.78–1.14)4260.87 (0.72–1.05)
 6–914,7914650.95 (0.80–1.14)28,5452450.99 (0.80–1.23)14,7122200.91 (0.73–1.13)13,842
Ptrend0.7300.9540.533
 Continuous, per 2 pts63,3621,8840.99 (0.91–1.08)28,5469721.03 (0.93–1.13)14,7109120.96 (0.87–1.07)13,842
  • Abbreviation: PYsubcohort, person-years in the subcohort.

  • aAdjusted for age at baseline (years), sex (men, women), cigarette smoking status (never, former, current), cigarette smoking frequency (cigarettes smoked per day, centered), cigarette smoking duration (years, centered), body mass index (kg/m2), alcohol consumption (g/day), daily energy intake (kcal), highest level of education (primary school or lower vocational, secondary school or medium vocational, higher vocational or university), and family history of bladder cancer (no, yes).

  • bNot adjusted for alcohol consumption.