Table 2.

Fully adjusted associations of aMED and mMED (including and excluding alcohol) with prostate cancer risk in the Netherlands Cohort Study

Prostate cancer
AllNonadvancedAdvanced
PYsubcohortCasesHR (95% CI)aAICCasesHR (95% CI)aAICCasesHR (95% CI)aAIC
aMEDr
 0–312,6371,4731.008541.004971.00
 4–513,3631,7131.09 (0.96–1.24)1,0481.14 (0.99–1.31)5451.03 (0.88–1.21)
 6–84,8176821.14 (0.96–1.36)55,7894271.22 (1.01–1.48)33,5132141.08 (0.87–1.35)18,198
Ptrend0.1390.0370.483
 Continuous, per 2 pts30,8163,8681.09 (1.01–1.17)55,7802,3291.12 (1.04–1.22)33,5051,2561.06 (0.96–1.17)18,195
aMEDb
 0–39,8331,1561.006661.003921.00
 4–513,7221,6611.03 (0.89–1.18)1,0081.07 (0.92–1.25)5280.97 (0.81–1.15)
 6–97,2611,0511.19 (1.02–1.40)55,7786551.28 (1.08–1.53)33,5053361.14 (0.93–1.39)18,192
Ptrend0.0650.0120.376
 Continuous, per 2 pts30,8163,8681.09 (1.01–1.17)55,7772,3291.12 (1.04–1.21)33,5031,2561.07 (0.98–1.17)18,192
mMEDr
 0–311,5361,3291.007901.004371.00
 4–514,1761,8571.10 (0.97–1.26)1,1111.11 (0.96–1.28)6141.12 (0.95–1.32)
 6–85,1046821.10 (0.92–1.31)55,7904281.17 (0.97–1.41)33,5192051.01 (0.81–1.26)18,196
Ptrend0.2850.1110.889
 Continuous, per 2 pts30,8163,8681.07 (0.99–1.16)55,7872,3291.11 (1.02–1.21)33,5111,2561.02 (0.92–1.13)18,197
mMEDb
 0–38,1289551.005711.003101.00
 4–514,8281,8171.00 (0.87–1.16)1,0690.99 (0.84–1.16)6121.05 (0.87–1.26)
 6–97,8601,0961.12 (0.95–1.32)55,7886891.18 (0.99–1.41)33,5123341.07 (0.87–1.31)18,197
Ptrend0.1220.0340.577
 Continuous, per 2 pts30,8163,8681.07 (1.00–1.16)55,7842,3291.11 (1.02–1.20)33,5091,2561.04 (0.95–1.14)18,195
  • Abbreviation: PYsubcohort, person-years in the subcohort.

  • aAdjusted for age at baseline (years), body mass index (kg/m2), alcohol consumption (g/day), daily energy intake (kcal), highest level of education (primary school or lower vocational, secondary school or medium vocational, higher vocational or university), and family history of prostate cancer (no, yes).

  • bNot adjusted for alcohol consumption.