Table 4.

HRs (95% confidence intervals) for colorectal cancer according to quintiles of acrylamide intake

Quintiles of energy-adjusted acrylamide intake
Quintile 1Quintile 2Quintile 3Quintile 4Quintile 5
TotalHR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)P for trend
Colorectal cancer
Number of subjects87,62817,52617,52617,52517,52617,525
 Person-years1,342,251265,817268,888269,901269,358268,286
 Number of cases2,470569554463458426
 Age- and area-adjusted modela1.00 (Reference)1.02 (0.91–1.15)0.89 (0.78–1.00)0.92 (0.81–1.04)0.89 (0.78–1.01)0.015
 Multivariable modelb1.00 (Reference)1.06 (0.94–1.19)0.93 (0.82–1.05)0.97 (0.85–1.10)0.94 (0.83–1.08)0.172
 Multivariable model (excluding cases <3 y)b1.00 (Reference)1.07 (0.95–1.22)0.96 (0.84–1.10)0.95 (0.83–1.09)0.97 (0.84–1.12)0.258
Colon cancer
 Number of cases1,721410384328314285
 Age- and area-adjusted modela1.00 (Reference)0.98 (0.85–1.12)0.87 (0.75–1.00)0.87 (0.75–1.01)0.83 (0.71–0.97)0.005
 Multivariable modelb1.00 (Reference)1.01 (0.88–1.16)0.91 (0.78–1.06)0.92 (0.79–1.07)0.89 (0.76–1.04)0.068
Rectal cancer
 Number of cases749159170135144141
 Age- and area-adjusted modela1.00 (Reference)1.14 (0.92–1.42)0.94 (0.74–1.18)1.03 (0.82–1.30)1.02 (0.81–1.30)0.856
 Multivariable modelc1.00 (Reference)1.17 (0.94–1.45)0.97 (0.76–1.22)1.07 (0.84–1.35)1.06 (0.83–1.35)0.927
  • Abbreviations: 95% CI = 95% confidence intervals.

  • aAge- and area-adjusted model adjusted for age (continuous), sex and area (10 public health center areas).

  • bMultivariable model additionally adjusted for: smoking status (never, former, current, missing), body mass index (<23.0, 23.0–24.9, 25.0–26.9, >=27.0 kg/m2, missing), physical activity (continuous), intakes of alcohol (<150, ≧150 g/week), and energy-adjusted consumption of vegetables, fruits, meat, and dairy (continuous).

  • cMultivariable model additionally adjusted for: smoking status (never, former, current, missing), body mass index (<23.0, 23.0–24.9, 25.0–26.9, ≥27.0 kg/m2, missing), intakes of alcohol (<150, ≧150 g/week), and energy-adjusted consumption of vegetables, fruits, meat, and dairy (continuous). Physical activity was not included since it is not considered a protective factor for rectal cancer.