Table 4.

Fully adjusted associations of aMEDr (per two-point increment) with prostate cancer risk for various subgroups in the Netherlands Cohort Study

Prostate cancer
AllNonadvancedAdvanced
CasesHR (95% CI)a,bCasesHR (95% CI)a,bCasesHR (95% CI)a,b
Overall3,8681.09 (1.01–1.17)2,3291.12 (1.04–1.22)1,2561.06 (0.96–1.17)
Alcohol consumptionc
 0 g/day4881.11 (0.91–1.35)2911.10 (0.89–1.37)1541.22 (0.93–1.61)
 >0–<15.0 g/day1,8911.15 (1.03–1.28)1,1351.20 (1.06–1.36)6281.08 (0.94–1.24)
 ≥15.0 g/day1,4891.02 (0.90–1.16)9031.07 (0.93–1.22)4740.99 (0.85–1.15)
Pinteractiond0.4840.5060.387
Body mass indexe
 ≥18.5–<25.0 kg/m22,0541.08 (0.97–1.20)1,2561.12 (1.00–1.25)6461.07 (0.94–1.22)
 ≥25.0 kg/m21,8041.10 (0.98–1.23)1,0671.14 (1.01–1.29)6081.05 (0.92–1.21)
Pinteractiond0.6990.6230.897
Highest level of educationf
 Primary school or lower vocational1,5721.03 (0.92–1.17)9291.07 (0.93–1.22)5250.97 (0.84–1.13)
 Secondary school or medium vocational1,4051.06 (0.95–1.20)8271.12 (0.98–1.27)4701.05 (0.91–1.22)
 Higher vocational or university8911.24 (1.04–1.47)5731.26 (1.04–1.52)2611.27 (1.01–1.60)
Pinteractiond0.2350.3620.188
Family history of prostate cancerg
 No3,7311.10 (1.02–1.18)2,2441.14 (1.05–1.24)1,2141.07 (0.97–1.18)
 Yes1370.85 (0.53–1.38)850.84 (0.50–1.41)420.85 (0.47–1.54)
Pinteractiond0.1910.1640.363
Follow-up period
 1986–19949851.06 (0.96–1.18)4551.08 (0.95–1.24)3971.09 (0.95–1.25)
 1995–20062,8831.09 (1.01–1.19)1,8741.13 (1.04–1.24)8591.05 (0.94–1.17)
Pinteractiond0.6110.4560.440
  • aAll HRs were estimated per two-point increment in aMEDr.

  • bAdjusted for age at baseline (years), body mass index (kg/m2), alcohol consumption (g/day), daily energy intake (kcal), highest level of education (primary school or lower vocational, secondary school or medium vocational, higher vocational or university), and family history of prostate cancer (no, yes).

  • cNot adjusted for alcohol consumption.

  • dP-values for interaction were obtained by testing the statistical significance of interaction terms between aMEDr and the stratifying covariates in fully adjusted models.

  • eNot adjusted for body mass index.

  • fNot adjusted for highest level of education.

  • gNot adjusted for family history of prostate cancer.