Table 1.

Characteristics of participants by liver fibrosis scores among men ages 40 years and older, NHANES 2001–2010

APRIFIB-4NFS
OverallNormalAbnormalaNormalAbnormalNormalAbnormal
Unweighted participants6,7056,5411646,3193866,139566
Age group, % (95% CI)
 40–49 years38.0 (36.2–39.9)37.9 (36.1–39.8)42.4 (32.3–53.2)39.0 (37.2–40.9)11.6 (7.3–17.7)40.0 (38.1–41.9)5.2 (3.8–7.1)
 50–59 years31.1 (29.4–32.8)31.1 (29.5–32.7)28.6 (19.1–40.3)31.6 (30.0–33.4)15.3 (10.5–21.7)32.0 (30.3–33.8)14.4 (10.5–19.5)
 60–69 years17.4 (16.5–18.4)17.4 (16.4–18.4)18.9 (13.8–25.3)17.3 (16.3–18.3)20.2 (15.5–25.9)16.8 (15.8–17.9)27.8 (23.4–32.6)
 70–79 years9.6 (9.0–10.3)9.7 (9.0–10.4)6.5 (3.7–11.1)9.0 (8.4–9.7)25.2 (21.1–29.7)8.2 (7.6–8.9)32.8 (29.0–36.7)
 ≥80 years3.9 (3.5–4.4)3.9 (3.5–4.4)3.7 (2.0–6.5)3.0 (2.6–3.5)27.8 (23.7–32.3)3.0 (2.6–3.4)19.7 (17.0–22.8)
Race/ethnicity, % (95% CI)
 White (non-Hispanic)77.1 (74.5–79.7)77.3 (74.7–79.9)67.4 (57.4–77.4)77.2 (74.6–79.7)76.4 (71.0–81.9)77.0 (74.2–79.5)79.8 (75.4–83.6)
 Black (non-Hispanic)8.6 (7.3–9.8)8.5 (7.2–9.7)14.4 (8.6–20.1)8.5 (7.3–9.7)10.6 (7.3–13.8)8.6 (7.4–9.9)8.3 (6.2–11.0)
 Mexican American/Other Hispanic9.6 (7.7–11.5)9.5 (7.6–11.4)12.5 (6.5–18.6)9.7 (7.8–11.6)7.1 (4.1–10.1)9.8 (8.0–11.9)6.6 (4.8–9.0)
 Other4.7 (3.8–5.6)4.7 (3.7–5.6)5.7 (0.7–10.7)4.7 (3.7–5.6)5.9 (2.7–9.1)4.7 (3.8–5.7)5.4 (3.5–8.1)
Education level, % (95% CI)
 Less than 9th grade7.4 (6.5–8.2)7.3 (6.4–8.1)11.0 (5.9–16.2)7.1 (6.3–7.9)14.3 (10.7–17.9)6.9 (6.1–7.8)15.0 (11.3–19.6)
 9–11th grade (includes 12th grade, no diploma)10.2 (9.2–11.3)10.1 (9.0–11.1)18.5 (10.3–26.7)10.1 (9.0–11.1)15 (10.1–19.9)10.1 (9.1–11.3)11.6 (9.2–14.6)
 High school graduate/GED or equivalent25.2 (23.8–26.6)25.0 (23.6–26.4)33.1 (24.7–41.6)25.2 (23.8–26.6)24.6 (18.6–30.6)25.5 (23.9–26.6)24.8 (21.0–29.0)
 Some college or associates degree27.4 (26.0–28.9)27.5 (26.1–29.0)22.4 (14.4–30.4)27.6 (26.2–29.1)21.8 (16.0–27.7)27.4 (26.0–29.0)27.3 (21.5–34.1)
 College graduate or above29.8 (27.6–32.0)30.1 (27.9–32.3)14.9 (7.2–22.6)30.0 (27.7–32.2)24.3 (18.1–30.5)30.3 (28.0–32.6)21.3 (16.9–26.4)
Drinking status, % (95% CI)
 Nondrinker or nonheavy drinker91.2 (90.3–92.1)91.6 (90.8–92.5)70.2 (62.3–78.1)91.4 (90.5–92.3)85.7 (81.4–90.1)91.0 (90.0–91.9)94.2 (91.6–96.0)
 Heavy drinker8.8 (7.9–9.7)8.4 (7.5–9.2)29.8 (21.9–37.7)8.6 (7.7–9.5)14.3 (9.9–18.6)9.0 (8.1–10.0)5.8 (4.0–8.4)
Smoking history, % (95% CI)
 Never41.7 (39.7–43.6)42.1 (40.1–44.1)23.9 (14.6–33.3)41.9 (39.9–43.9)35.2 (29.7–40.7)42.1 (40.0–44.1)35.3 (31.1–39.8)
 Ever58.3 (56.4–60.3)57.9 (55.9–59.9)76.1 (66.7–85.4)58.1 (56.1–60.1)64.8 (59.3–70.3)57.9 (55.9–60.0)64.7 (60.2–68.9)
BMI Category, % (95% CI)
 Normal/overweight (<30 kg/m2)65.4 (63.7–67.2)65.5 (63.8–67.3)62.0 (52.9–71.1)65.3 (63.5–67.1)69.1 (63–75.2)67.4 (65.6–69.1)32.5 (28.8–36.4)
 Obese (≥30 kg/m2)34.6 (32.8–36.3)34.5 (32.7–36.2)38.0 (28.9–47.1)34.7 (32.9–36.5)30.9 (24.8–37.0)32.6 (30.9–34.4)67.5 (63.6–71.2)
Diabetes status, % (95% CI)
 No diabetes63.5 (62.1–65.0)63.6 (62.2–65.0)61.9 (52.8–71.0)64.0 (62.5–65.4)51.7 (44–59.5)65.9 (64.4–67.3)24.5 (20.6–28.9)
 At risk for diabetes22.5 (21.4–23.7)22.6 (21.4–23.8)17.5 (9.6–25.3)22.4 (21.2–23.7)24.8 (19.2–30.4)22.3 (21.1–23.6)25.4 (21.2–30.1)
 Controlled diabetes5.8 (5.0–6.6)5.7 (4.9–6.6)7.7 (2.9–12.5)5.5 (4.7–6.3)12.5 (7.0–18.0)4.5 (3.8–5.4)26.7 (22.1–32.0)
 Uncontrolled diabetes8.2 (7.3–9.1)8.1 (7.2–9.0)12.9 (6.1–19.7)8.1 (7.2–9.0)10.9 (7.4–14.4)7.3 (6.4–8.2)23.4 (19.1–28.3)
Self-reported liver disease, % (95% CI)
 Never95.2 (94.5–95.8)95.6 (95.0–96.2)75.7 (64.7–84.1)95.6 (94.9–96.2)85.1 (78.8–89.8)95.4 (94.6–96.0)92.4 (88.4–95.1)
 Ever4.8 (4.2–5.5)4.4 (3.8–5.0)24.3 (15.9–35.3)4.4 (3.8–5.1)14.9 (10.2–21.2)4.6 (4.0–5.4)7.6 (4.9–11.6)
HCV Status, % (95% CI)
 HCV Negative96.7 (96.0–97.3)97.4 (96.7–97.9)65.3 (55.6–74.0)97.1 (96.4–97.6)86.2 (80.4–90.4)96.7 (96.0–97.3)96.1 (93.4–97.7)
 HCV Infected3.3 (2.7–4.0)2.6 (2.1–3.3)34.7 (26.0–44.4)2.9 (2.4–3.6)13.8 (9.6–19.6)3.3 (2.7–4.0)4.0 (2.3–6.6)
HBV Status, % (95% CI)
 Negative92.2 (91.2–93.0)92.4 (91.5–93.3)79.2 (70.0–86.1)92.4 (91.4–93.3)85.6 (79.8–89.9)92.3 (91.3–93.2)90.1 (86.6–92.7)
 Current or previous HBV infected7.8 (7.0–8.8)7.6 (6.7–8.5)20.8 (13.9–30.0)7.6 (6.7–8.6)14.4 (10.1–20.2)7.7 (6.8–8.7)9.9 (7.3–13.4)
 Chronic HBV infected0.5 (0.3–0.7)0.5 (0.3–0.7)1.2 (3.5–4.0)0.5 (0.3–0.7)0.5 (0.2–1.7)0.5 (0.3–0.7)0.3 (0.1–1.2)
  • aCut-off point for abnormal liver fibrosis score equates to advanced fibrosis (APRI >1, FIB-4 > 2.67, and NFS > 0.676).