Table 4.

HR and 95% CI for the association between dietary magnesium quintiles and colorectal cancer riska (ARIC 1993–2012)

Dietary magnesium (mg/day)58.68–185.35185.36–226.07226.08–265.62265.64–318.73318.79–792.01Ptrend
Number of cases4657475353
Person-years32,79332,66632,94032,99231,739
HR (95% CI)b1 (ref)1.19 (0.81–1.75)0.97 (0.64–1.46)1.08 (0.73–1.61)1.12 (0.75–1.67)0.63
HR (95% CI)c1 (ref)1.13 (0.74–1.71)0.85 (0.53–1.37)0.91 (0.54–1.54)0.77 (0.38–1.55)0.61
  • aFollow-up beginning at visit 3 (1993–1995). Dietary magnesium assessed as the average of visits 1 (1987–1989) and 3 (1993–1995).

  • bModel adjusted for age, sex, race, and study center.

  • cModel noted in footnote b further adjusted for total calories, dietary calcium, dietary fiber, BMI, physical activity, alcohol intake, smoking status, pack-years of smoking, aspirin use, HRT use, and diabetes.