Table 3.

Serum levels of 25(OH)D and OSa among patients with esophageal adenocarcinoma, stratified by clinical stage (n = 476)

25(OH)D QuartilesbN deaths/patientsHRc95% Confidence limits
Lymph node negative at diagnosisQ1 (highest)19/28REF
Q221/410.930.49–1.76
Q325/410.950.51–1.74
Q4 (lowest)27/411.000.55–1.82
Lymph node positive at diagnosisQ1 (highest)44/59REF
Q239/570.950.61–1.47
Q348/601.120.74–1.70
Q4 (lowest)42/531.190.77–1.83
Metastatic at diagnosisQ1 (highest)27/27REF
Q222/220.800.45–1.42
Q322/230.950.52–1.73
Q4 (lowest)24/240.690.39–1.24
  • aOS was calculated as time between date of blood draw and date of death or date last known to be alive.

  • bQuartiles of vitamin D were determined accounting for month of blood draw.

  • cModel adjusted for the main effect of vitamin D, age, sex, smoking status, the main effect of BMI categories, year of diagnosis, chemotherapy, radiation, time-dependent surgery, and baseline treatment, and baseline hazard was stratified by tumor stage by lymph node status.