Table 2.

Serum levels of 25(OH)D and OSa among patients with esophageal adenocarcinoma (n = 476)

25(OH)D QuartilesbN deaths/patientsHR95% CIP
1 (highest)90/114REF
282/1200.90(0.67–1.23)0.51
395/1241.03(0.76–1.38)0.87
4 (lowest)93/1180.98(0.72–1.33)0.90
Global P = 0.86
25(OH)D Clinical cut-off pointsc
 ≥40 ng/mL (≥100 nmol/L)14/16REF
 30–40 ng/mL (75–100 nmol/L)31/391.29(0.68–2.47)0.44
 20–30 ng/mL (50–75 nmol/L)124/1770.98(0.55–1.73)0.93
 10–20 ng/mL (25–50 nmol/L)159/2011.22(0.69–2.16)0.49
 <10 ng/mL (<25 nmol/L)32/430.98(0.50–1.92)0.96
Global P = 0.32
25(OH)D Continuous (ng/mL)c1.00(0.99–1.01)0.54
  • aOS was calculated as time between date of blood draw and date of death or date last known to be alive.

  • bEstimates come from model that additionally adjusted for age, sex, smoking status, BMI categories, year of diagnosis, time between diagnosis and blood draw, chemotherapy, radiation, time-dependent surgery, and baseline treatment was stratified by tumor stage by lymph node status. Quartiles of vitamin D were determined accounting for month of blood draw.

  • cEstimates come from model that additionally adjusted for age, sex, smoking status, BMI categories, season of blood draw, year of diagnosis, time between diagnosis and blood draw, chemotherapy, radiation, time-dependent surgery, and baseline treatment was stratified by tumor stage by lymph node status.