Case-only analysis of pathogenic variants in ILC for family history (FH) of breast cancer (BC)
| Carriers FH of BC vs. no FH in first-degree relative | Carriers FH of BC vs. no FH in any relative | |||
|---|---|---|---|---|
| Gene | OR (95% CI) | P | OR (95% CI) | P |
| BRCA2 | 2.36 (1.05–5.31) | 0.043 | 2.25 (1.02–4.98) | 0.046 |
| CHEK2 | 2.59 (1.02–6.60) | 0.067 | 3.95 (1.42–11.01) | 0.008 |
| PALB2 | 2.94 (0.83–10.45) | 0.097 | 3.26 (0.84–12.65) | 0.105 |
| CDH1 | 2.95 (0.49–17.73) | 0.238 | 2.11 (0.35–12.65) | 0.415 |
| BRCA1 | 0 | 1 | — | 0.419 |
| TP53 | — | — | — | — |