Table 1.

Association of known pathogenic variants with ILC and LCIS in women ≤60 years of age by gene (1,434 ILC, 368 LCIS cases, and 1,611 controls)

GenePathogenic variants in ILC casesPathogenic variants in LCIS casesPathogenic variants in controlsOR (95% CI) for ILCP value for ILCOR (95% CI) for LCISP value for LCISP value case only (ILC vs. LCIS)
BRCA2271215.44 (3.66–65.04)1.7 × 10−72.19 (0.20–24.24)0.460.030
CHEK2191154.31 (1.61–11.58)1.7 × 10−39.90 (3.42–28.66)1.4 × 10−50.037
PALB2111112.45 (1.60–95.52)2.2 × 10−34.39 (0.27–70.30)0.340.48
CDH15100.020.181.00
BRCA11000.5
TP53000
  • Abbreviation: CI, confidence interval.