Table 2.

Hazard Ratios for lung cancer across quartiles of plasma TPO, sTM, sP-Selectin, sGPIIb/IIIa and fibrinogen

Quartile 1Quartile 2Quartile 3Quartile 4Pval cont
TPOMediana254304365446
n cases/subcohort59/59239/59341/59451/589
Model 1Ref0.68 (0.44–1.04)0.68 (0.45–1.04)0.85 (0.57–1.27)0.49
Model 2Ref0.69 (0.42–1.13)0.89 (0.55–1.44)0.86 (0.54–1.38)0.79
sTMMediana2.262.813.173.96
n cases/subcohort57/59143/59040/59550/590
Model 1Ref0.72 (0.48–1.10)0.67 (0.44–1.03)0.81 (0.54–1.21)0.45
Model 2Ref0.79 (0.48–1.30)0.80 (0.48–1.31)1.05 (0.65–1.69)0.46
sGPIIb/IIIaMediana275350422585
n cases/subcohort44/59038/58754/58752/583
Model 1Ref0.90 (0.57–1.42)1.24 (0.81–1.88)1.24 (0.81–1.88)0.26
Model 2Ref0.95 (0.56–1.61)1.06 (0.65–1.73)1.27 (0.78–2.08)0.45
sP-SelectinMediana20.225.232.742.6
n cases/subcohort17/59432/59456/59485/585
Model 1Ref1.92 (1.05–3.50)3.22 (1.84–5.64)5.04 (2.95–8.60)<0.001
Model 2Ref1.64 (0.85–3.18)2.71 (1.48–4.97)2.77 (1.55–4.96)<0.001
Model 3Ref1.50 (0.77–2.95)2.60 (1.41–4.78)2.51 (1.39–4.52)0.002
FibrinogenMediana3,2293,6053,9954,653
n cases/subcohort21/59734/59452/59083/587
Model 1Ref1.55 (0.89–2.72)2.31 (1.35–3.93)3.88 (2.34–6.42)<0.001
Model 2Ref1.21 (0.65–2.23)1.49 (0.83–2.67)2.03 (1.16–3.55)<0.001
Model 3Ref1.22 (0.66–2.25)1.48 (0.82–2.65)1.91 (1.09–3.34)0.002
  • NOTE: Results from Prentice-weighted Cox proportional hazards regression analyses. Model 1 adjusted for age and sex. Model 2 adjusted for age, sex, smoking (never smokers, long-term quitters ≥ 10 years, short-term quitters < 10 years, light smokers < 15 cigarettes per day, heavy smokers ≥ 15 cigarettes per day), lifetime alcohol intake (g/d), current aspirin use (yes/no), CRP (mg/dl), physical activity (Cambridge Index), BMI (kg/m2), height (cm) and education level (primary school, secondary school, university degree). Model 3 additionally adjusted for sP-Selectin or fibrinogen, respectively. Numbers for the subcohort do not include incident cancer cases (n = 17).

  • aMedian concentrations in pg/mL (thrombopoietin), in ng/mL (sTM, sP-Selectin, sGPIIb/IIIa) and in μg/mL (Fibrinogen).