Case-only analysis of pathogenic variants in ILC by age
| Carriers ≤40 vs. >40 | Carriers ≤50 vs. 51–60 | |||
|---|---|---|---|---|
| Gene | OR (95% CI) | P | OR (95% CI) | P |
| BRCA2 | 4.62 (1.74–12.23) | 0.009 | 4.83 (1.95–12.01) | 0.0003 |
| CHEK2 | 0.00 (0.00–0.00) | 0.62 | 0.78 (0.31–1.99) | 0.65 |
| PALB2 | 0.00 (0.00–0.00) | 1 | 1.12 (0.34–3.68) | 1 |
| CDH1 | 13.14 (2.19–78.75) | 0.022 | 2.02 (0.34–12.1) | 0.66 |
| BRCA1 | — | 0.05 | — | 0.43 |
| TP53 | — | — | — | — |