Table 1.

Study and patient characteristics of included articles

ReferenceFirst author, yearSource populationRCT or ObsSingle- or multi-centerStudy designNumber, DCIS patientsNumber, iIBC eventsPeriodMean follow-up (years)Adjacent invasion included?Treatment
17Rakovitch, 2018HQECOG E5194, Ontario DCIS CohortRCTa, ObsMultiCohort773651994–20039.4N/aBCS alone
18Visser, 2018HQNetherlands Cancer RegistryObsMultiCase–control6742001989–200412.0NoBCS alone
19Pruneri, 2017European Institute of OncologyObsSingleCohort1,4881361997–20088.2N/aAll modalities
20Molinaro, 2016HQSEER Northern CaliforniaObsMultiCase–control1,4921671983–199612.6NoBCS alone
21Borgquist, 2015Uppland, Västmanland (Sweden)ObsMultiCohort324461986–200415.3N/aAll modalities
22Williams, 2015DCIS I, IBIS II, IRESSA trial, ERISAC, lapatinib DCISRCTMultiCohort314221990–20105.0YesAll modalities
23Curigliano, 2015HQEuropean Institute of OncologyObsSingleCohort1,6672011996–20087.6N/aAll modalities
24Cheung, 2014HQWest Midlands Cancer RegistryObsMultiCohort3,9302971988–2008N/aN/aAll modalities
25Generali, 2014John Radcliffe Hospital, Royal Brisbane and Women's HospitalObsMultiCohort17425N/a12.1N/aAll modalities
26Kong, 2014HQOntario Cancer RegistryObsMultiCohort1,6071481994–200310NoBCS+RT
27v Bockstal, 2013Ghent University HospitalObsSingleCohort64121991–20039.3YesAll modalities
28Solin, 2013ECOG E5194RCTaMultiCohort327201997–20028.8N/aBCS ± HT
29Donker, 2013EORTCRCTMultiCohort1,0101231986–199615.8NoBCS ± RT
30Collins, 2013HQKPNC, KPSC, HPHCObsMultiCase–control6192251990–20014.8N/aBCS ± RT
31Holmberg, 2013HQSweDCISRCTMultiCase–control1,046N/aN/aN/aYesBCS ± RT
32Knudsen, 2012Thomas Jefferson University HospitalObsSingleCohort236271978–20089.0NoBCS alone
33Alvarado, 2012University of Texas MD Anderson Cancer CenterObsSingleCohort2,037161996–20095.2N/aAll modalities
34Rakovitch, 2012HQSunnybrook Health Sciences CentreObsSingleCohort213211982–20007.7N/aBCS ± RT
35Han, 2012HQSunnybrook Health Sciences CentreObsSingleCohort180221987–20007.8YesBCS ± RT
36Witkiewicz, 2011Thomas Jefferson University HospitalObsSingleCohortb12616N/aN/aN/aBCS alone
37Wapnir, 2011NSABP B-17, NSABP B-24RCTMultiCohort2,6122631985–199414.7N/aBCS±RT ±HT
38Falk, 2011Norwegian Breast Cancer Screening ProgrammeObsMultiCohort3,046961993–20075.2NoAll modalities
39Tunon-de-Lara, 2010Institut BergonieObsSingleCohort812471971–20019.8NoAll modalities
40Zhou, 2010Uppland, Västmanland (Sweden)ObsMultiCohort392341986–200410.2N/aAll modalities
41Pinder, 2010UKCCR/ANZRCTMultiCohort1,224551990–1998N/aYesBCS ± RT ± HT
42Kerlikowske, 2010HQSEER Northern CaliforniaObsMultiCase–control329721983–19948.2NoBCS alone
43Witkiewicz, 2009Thomas Jefferson University HospitalObsSingleCohortb7811N/a12.2N/aBCS alone
44Nofech-Mozes, 2008Sunnybrook Health Sciences CentreObsSingleCohort133211982–20008.9YesBCS alone
45Rakovitch, 2007Sunnybrook Health Sciences CentreObsSingleCohort615361982–20005.9YesBCS ± RT
46Ringberg, 2007HQSweDCISRCTMultiCase–control1,0461551987–19995.2N/aBCS ± RT
47Hwang, 2007HQBreast Cancer Surveillance ConsortiumObsMultiCohort3,274831993–20053.2NoAll modalities
48Smith, 2006HQSEERObsMultiCohort3,4091071992–19995.0N/aBCS ± RT
49Li, 2006HQSEERObsMultiCohort37,6921,5041988–2002N/aN/aBCS ± RT
50Bijker, 2006EORTCRCTMultiCohort1,0101081986–199610.5NoBCS ± RT
51Warren, 2005SEERObsMultiCohort1,103621991–19927.5NoBCS ± RT
52Kerlikowske, 2003HQSEER Northern CaliforniaObsMultiCohort1,036711983–19946.5NoBCS alone
53Teo, 2003Merseyside (UK)ObsMultiCase—control52121989–19995.3NoAll modalities
54Bijker, 2001HQEORTCRCTMultiCohort863661986–19965.4NoBCS ± RT
55Wärnberg, 2001Swedish Cancer RegistryObsMultiCase–control570701960–199610NoAll modalities
56Habel, 1998SEER WashingtonObsMultiCohort709551980–19925.2N/aBCS ± RT
  • NOTE: “All modalities” consistent of BCS alone, BCS+RT/HT, and mastectomy.

  • Abbreviations: HPHC, Harvard Pilgrim Health Care; KPNC, Kaiser Permanente Northern California; KPSC, Kaiser Permanente Southern California; N/a, data not available; Obs, observational study; RCT, randomized clinical trial.

  • aNonrandomized clinical trial.

  • bSelection of cohort used in analysis.