Table 2.

Upstream regulators of the upregulated transcripts (n = 727) identified in top canonical inflammatory associated pathways: IPA

Progressed upregulated (n = 364)Not progressed upregulated (n = 363)
Top canonical pathwaysPTop canonical pathwaysP
Pathogenesis of MS1.31E-05Role of 17A in psoriasis7.81E-05
EIF2 Signaling3.02E-05Histamine degradation2.57E-03
Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza8.83E-04Inhibition of angiogenesis by TSP15.44E-03
IL9 Signaling1.36E-03Neuregulin signaling6.43E-03
Communication between innate and adaptive immunity3.11E-03
Upstream regulatorsPUpstream regulatorsP
SAMSN11.36E-10Lipopolysaccharide8.29E-09
IFNLR19.87E-09TNF2.21E-08
STAT11.33E-09PGE21.68E-07
TBK11.35E-09CSF21.84E-07
IRF31.42E-09PD980593.33E-07
TLR31.46E-10Immunoglobulin5.28E-07
Salmonella enterica serotype1.92E-09IL29.43E-06
IFNA25.05E-09UO1261.65E-06
TLR96.48E-09TGFB12.15E-06
STAT27.92E-09MYD882.70E-06
PTPRJ7.92E-09IL43.40E-06
IRF58.35E-09Diethylstilbestrol1.25E-05
DOCK81.01E-08EGR11.40E-05
IRF71.18E-08EGF1.46E-05
TMEM1731.48E-089,10-Dimethyl-1,2-benzanthracene2.15E-05
TREM11.97E-08ATP-gamma-S2.17E-05
TLR42.07E-08Tretinoin2.28E-05
IFNAR12.16E-08LY2940022.53E-05
IFNL15.57E-08Tributyrin2.74E-05
ELANE7.47E-05
IL17A3.53E-05
IL104.14E-05
SMAD44.31E-05
Methylprednisolone4.68E-05
IL64.89E-05
IL14.97E-05
FoxP35.12E-05
α-Catenin5.56E-05