Table 1.

Baseline characteristics at cancer diagnosis of men with prostate cancer and tumor transcriptome profiling in TCGA, HPFS, and PHS, by PLZF mRNA expression (low: first quartile; normal: all higher quartiles)

TCGAHPFSPHS
PLZF expressionaLowNormalLowNormalLowNormal
n842496818633117
Age, median (range)64 (46–74)61 (43–76)65 (47–76)66 (49–80)65 (55–79)66 (51–81)
Gleason score in grade groups, n (%)
 5–69 (11)56 (22)4 (6)20 (11)3 (9)30 (26)
 3+430 (36)72 (29)20 (29)71 (38)11 (33)37 (32)
 4+323 (27)55 (22)22 (32)52 (28)10 (30)18 (15)
 810 (12)35 (14)8 (12)13 (7)5 (15)17 (15)
 9–1012 (14)31 (12)14 (21)30 (16)4 (12)15 (13)
Clinical stage, n (%)
 T1/T284 (100)249 (100)56 (85)158 (86)29 (88)107 (93)
 T35 (8)16 (9)3 (9)3 (3)
 T4/N1/M15 (8)9 (5)1 (3)5 (4)
PSA,b n (%)
 <47 (15)12 (9)7 (12)17 (11)5 (19)12 (12)
 4–1030 (65)78 (55)27 (47)90 (58)15 (58)64 (62)
 10–207 (15)30 (21)13 (22)30 (19)3 (12)17 (17)
 >202 (4)21 (15)11 (19)17 (11)3 (12)10 (10)
 Missing381081032714
Tissue source, n (%)
 Prostatectomy84 (100)249 (100)64 (94)172 (92)29 (88)104 (89)
 TURPc4 (6)14 (8)4 (12)13 (11)
PLZF copy numberNot availableNot available
 Gaind3 (4)16 (6)
 Diploid63 (75)215 (86)
 Heterozygous deletion11 (13)11 (4)
 Homozygous deletion7 (8)7 (3)
PTEN status
 Intact/diploid43 (51)197 (79)32 (68)97 (82)11 (50)55 (79)
 Loss/any deletion41 (49)52 (21)15 (32)21 (18)11 (50)15 (21)
  • aCategorized as: low, first quartile of mRNA expression; normal, all higher quartiles combined.

  • bSerum prostate specific antigen, in ng/mL.

  • cTransurethral resection of the prostate. Includes one lymph node sample in a patient from PHS.

  • dIncludes one amplification event in the mRNA expression category “normal.”