Table 2.

Reported NRI values from included studies

ModelNo. of risk factorsNo. of SNPsNRI Value (95% CI)aClassification categoriesAuthor, year
BCRAT (5–6 risk factors of BCRAT)67Overall: 0.085<1.5%,Mealiffe, 2010
57Overall: 0.0281.5%–2.0%,Dite, 2013
35–39 years: 0.021>2.0%
40–49 years: 0.074
50–59 years: −0.029
5770.066 (0.019–0.110)Dite, 2016
6750.033 (0.025–0.089)<1.5%,Allman, 2015
6710.082 (0.003–0.162)1.5%–<2.0%,
≥2.0%
Partial BCRAT (2–4 risk factors of BCRAT)2 + 4510.062<1.0%,Lee, 2014
1.0%–<1.5%,
1.5%–<2.0%,
2.0%–<2.5%
≥2.5%
BOADICEA8770.040 (0.007–0.073)<1.5%,Dite, 2016
BRCAPRO8770.063 (0.030–0.094)1.5%–2.0%,
IBIS12770.052 (0.015–0.088)>2.0%
6750.060 (0.005–0.113)<1.5%,Allman, 2015
6710.181 (0.085–0.273)1.5%–<2.0%,
≥2.0%
BCSC576Case: 0.110 (0.070–0.150), Control 0.020 (−0.010–0.050)<3%,Vachon, 2015
≥3%
Other models10180.083<1%,Hüsing, 2012
1%–<1.66%,
1.66%–<3.5%
>3.5%
  • Abbreviations: BCRAT, Breast Cancer Risk Assessment Tool (6); BCSC, Breast Cancer Surveillance Consortium (11, 12); BOADICEA, Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (9, 10); BRCAPRO (8); CI, confidence interval; IBIS, International Breast Intervention Study (7); NRI, net reclassification improvement.

  • aPositive NRI values indicate an overall correct reclassification.