Table 2.

PCMTD1 mutations

SOCS Box (240–356)
Study PMIDCancerPCMT (1–239)BC (∼16)Spacer (∼82)Cul5 Box (∼15)% of Cases
22960745Lung SQCCYesNoYesYes4%
24793135Aggressive rhabdomyosarcomaNoNoYesNo65%
22622578MelanomaNoYesYesYes28%
22610119ProstrateNoNoNoYes1%
24816255Gastric carcinomaNoNoYesNo7%
25855536Pancreatic cancerNoYesYesNo7%
24120142GlioblastomaYesNoYesNo1%
AppKYLung SQCCNoNoYesYes18%
  • NOTE: The PCMTD1 mutations reported in the literature are in the C-terminal SOCS Box. PCMTD1 mutations in cancers are rarely found in the PCMT domain. The vast majority of mutations (except 1 case in TCGA Lung SQCC and 1 case in Glioblastoma) occur in the SOCS Box.