Table 1.

Selected characteristics of the trial population (n = 2,524)

Control: Vitamin D (n = 1,267)Missing (n)Intervention: Folic acid, vitamin B12, and vitamin D (n = 1,257)Missing (n)P
Age(years)a74.0 (6.2)073.9 (6.6)00.63
Sex (% women)48.6050.400.36
Education years (%)200.30
 5–1067.365.3
 11–1832.732.7
Alcohol consumption (%)100.57
 Light66.766.9
 Moderate28.829.6
 Excessive4.03.0
 Very excessive0.40.5
Smoking status (%)000.80
 Never33.933.5
 Current9.410.2
 Former56.756.3
BMIa27.2 (4.0)827.1 (4.0)100.67
Homocysteine (μmol/L)b14.5 (13.0–16.7)014.3 (13.0–16.5)00.40
MTHFR (%)1611450.27
 CC42.844.2
 CT41.239.3
 TT12.612.3
Folic acid supplement use (%)000.94
 Yes14.814.5
 No83.383.8
 When necessary1.91.8
Vitamin B12 supplement use (%)000.96
 Yes15.114.5
 No83.279.3
 When necessary1.91.8
Vitamin D supplement use (%)000.85
 Yes19.718.8
 No78.579.3
 When necessary1.71.8
Serum 25(OH)D (nmol/L)a55.8 (23.9)3056.0 (25.9)260.82
Serum folate (nmol/L)a20.1 (7.3)4420.3 (7.4)450.47
Serum vitamin B12 (pmol/L)a283.6 (115.0)17289.7 (116.2)110.19
Serum HoloTC (pmol/L)a70.9 (42.5)1174.3 (44.5)70.05c