Table 3.

The association between prediagnosis alcohol use and the OS of HNC patients by subsite

Prediagnosis alcohol useOral cancerOropharyngeal + hypopharyngeal cancerLaryngeal cancerOropharyngeal + hypopharyngeal cancer + laryngeal cancer
n (%)HR (95% CI)aPn (%)HR (95% CI)aPn (%)HR (95% CI)aPn (%)HR (95% CI)aP
Never + occasional177 (37.90)Referent29 (16.48)Referent32 (37.21)Referent61 (23.28)Referent
Former56 (11.99)1.29 (0.69–2.40)0.4230 (17.05)2.28 (0.93–5.60)0.079 (10.47)1.54 (0.30–7.96)0.6139 (14.89)2.56 (1.22–5.37)0.01
Current234 (50.11)1.10 (0.72–1.69)0.66117 (66.48)1.55 (0.70–3.44)0.2845 (52.33)1.39 (0.47–4.15)0.55162 (61.83)1.81 (0.97–3.38)0.06
Former + current290 (62.10)1.14 (0.75–1.71)0.54147 (83.53)1.69 (0.77–3.69)0.1954 (62.80)1.42 (0.49–4.07)0.52201 (76.72)1.95 (1.06–3.59)0.03
Frequency
 Never160 (34.26)Referent26 (14.77)Referent27 (31.40)Referent53 (20.23)Referent
 Monthly17 (3.64)0.25 (0.03–1.83)0.173 (1.70)5 (5.81)1.34 (0.15–12.03)0.798 (3.05)0.51 (0.07–3.94)0.52
 Weekly43 (9.21)1.18 (0.60–2.32)0.6423 (13.07)0.87 (0.29–2.58)0.799 (10.47)1.66 (0.30–9.06)0.5632 (12.21)1.24 (0.50–3.09)0.64
 Daily232 (49.68)1.08 (0.70–1.66)0.73122 (69.32)1.51 (0.68–3.32)0.3144 (51.16)1.49 (0.46–4.83)0.51166 (63.36)1.90 (1.00–3.61)0.05
 Unknown15 (3.21)2 (1.14)1 (1.16)3 (1.15)
P trend = 0.58P trend = 0.13P trend = 0.51P trend = 0.02
Amountb
 Never147 (35.34)Referent24 (14.91)Referent26 (32.91)Referent50 (20.83)Referent
 Light63 (15.14)0.87 (0.45–1.70)0.6924 (14.91)0.78 (0.25–2.42)0.6610 (12.66)1.98 (0.33–11.88)0.4634 (14.17)1.26 (0.48–3.26)0.64
 Moderate58 (13.94)1.29 (0.69–2.38)0.4329 (18.01)1.13 (0.41–3.12)0.817 (8.86)2.58 (0.43–15.48)0.3036 (15.00)1.81 (0.76–4.29)0.18
 Heavy133 (31.97)1.02 (0.62–1.69)0.9282 (50.93)1.71 (0.72–4.08)0.2235 (44.30)1.73 (0.43–6.94)0.44117 (48.75)2.23 (1.09–4.59)0.03
 Unknown15 (3.61)2 (1.24)1 (1.27)3 (1.25)
P trend = 0.76P trend = 0.05P trend = 0.46P trend = 0.01
Drink-yearsc
 0147 (35.34)Referent24 (14.91)Referent26 (32.91)Referent50 (20.83)Referent
 0.1–54.994 (22.60)0.88 (0.49–1.58)0.6741 (25.47)1.09 (0.42–2.85)0.8510 (12.66)2.88 (0.58–14.28)0.2051 (21.25)1.79 (0.80–4.02)0.16
 55–159.975 (18.03)1.24 (0.70–2.19)0.4746 (28.57)1.17 (0.45–3.02)0.7518 (22.78)1.06 (0.18–6.33)0.9564 (26.67)1.52 (0.68–3.41)0.31
 160 or more73 (17.55)1.10 (0.62–1.97)0.7446 (28.57)1.94 (0.78–4.79)0.1522 (27.85)2.32 (0.55–9.72)0.2568 (28.33)2.55 (1.20–5.43)0.01
 Unknown27 (6.49)4 (2.48)3 (3.80)7 (2.92)
P trend = 0.54P trend = 0.07P trend = 0.39P trend = 0.02
  • Abbreviation: N, number.

  • aHR and 95% CI were calculated using Cox proportional hazards model.

  • bLight: < 14 g/day; moderate: 14–42 g/day; heavy: > 42 g/day.

  • c1 drink-year = 1 drink (14 grams of alcohol) per day x 1 year.