Table 2.

Risk for thyroid SMN associated with previously established LTL-related SNPs

SNPChrNearby geneEffect alleleOther alleleEAF in EURaPublished betaPublished PReferenceUnadjusted HR (95% CI)PAdjusted HRb (95% CI)P
rs111255292ACYP2AC0.110.0657.5E−10Codd et al.1.08 (0.75–1.55)0.671.10 (0.74–1.64)0.64
rs109365993TERCCT0.760.1002.5E−31Codd et al.0.99 (0.73–1.33)0.951.04 (0.75–1.44)0.83
rs76759984NAF1GA0.760.0484.4E−16Codd et al.0.88 (0.65–1.19)0.410.93 (0.67–1.29)0.67
rs27361005TERTCA0.500.0854.4E−19Codd et al.0.89 (0.69–1.15)0.360.83 (0.63–1.08)0.17
rs942090710OBFC1CA0.130.1426.9E−11Codd et al.1.09 (0.78–1.52)0.601.06 (0.74–1.52)0.74
rs253591314DCAF4GA0.780.1036.4E−10Mangino et al.0.81 (0.62–1.06)0.130.80 (0.59–1.06)0.12
rs302723417CTC1CT0.280.0642.3E−08Mangino et al.1.18 (0.85–1.63)0.321.10 (0.78–1.53)0.60
rs810576719ZNF208GA0.120.0191.1E−09Codd et al.1.25 (0.95–1.63)0.111.08 (0.79–1.48)0.62
rs75501720RTEL1GA0.690.0496.7E−09Codd et al.0.80 (0.52–1.22)0.300.91 (0.59–1.42)0.68
Unweighted GRS0.98 (0.89–1.09)0.760.96 (0.86–1.07)0.47
Weighted GRS1.17 (0.34–4.00)0.800.81 (0.22–2.98)0.76
  • aEstimated allele frequency (EAF) in Europeans (EUR) from the 1000 Genomes Project.

  • bAdjusted for birth year, initial cancer type, age at diagnosis, sex, thyroid nodules, radiation, radiation to the neck (Y/N), radiation dose to the neck, and alkylating agent.