Table 4.

The association between prediagnosis alcohol use and the OS of HNC patients by ADH1B genotypes or ALDH2 genotypes

ADH1BALDH2
TT (*2/*2) (fast)CT (*1/*2) + CC (*1/*1) (slow)GG (*1/*1) (normal)AG (*1/*2) (slow) + AA (*2/*2) (nonfunctional)
Prediagnosis alcohol usen (%)HR (95% CI)aPn (%)HR (95% CI)aPn (%)HR (95% CI)aPn (%)HR (95% CI)aP
Never + occasional137 (37.03)Referent93 (26.80)Referent69 (22.85)Referent161 (38.80)Referent
Former45 (12.16)1.88 (1.00–3.56)0.0548 (13.83)1.38 (0.70–2.71)0.3545 (14.90)1.05 (0.49–2.25)0.9148 (11.57)2.23 (1.24–3.98)0.007
Current188 (50.81)1.78 (1.13–2.82)0.01206 (59.37)0.96 (0.57–1.60)0.86188 (62.25)1.04 (0.59–1.83)0.91206 (49.64)1.56 (1.01–2.41)0.04
Former + current233 (62.97)1.80 (1.15–2.81)0.01254 (73.20)1.03 (0.63–1.70)0.90233 (77.15)1.04 (0.60–1.80)0.90254 (61.21)1.68 (1.10–2.54)0.02
Frequency
 Never124 (33.51)Referent81 (23.34)Referent56 (18.54)Referent149 (35.90)Referent
 Monthly13 (3.51)0.32 (0.04–2.33)0.2612 (3.46)0.32 (0.04–2.39)0.2713 (4.30)0.57 (0.13–2.51)0.4612 (2.89)
 Weekly40 (10.81)1.55 (0.78–3.08)0.2134 (9.80)0.80 (0.34–1.89)0.6138 (12.58)0.89 (0.38–2.05)0.7836 (8.67)1.41 (0.69–2.88)0.34
 Daily185 (50.00)1.74 (1.10–2.77)0.02210 (60.52)0.99 (0.59–1.66)0.96183 (60.60)1.01 (0.56–1.83)0.97212 (51.08)1.56 (1.02–2.40)0.04
 Unknown8 (2.16)10 (2.88)12 (3.97)6 (1.45)
P trend = 0.01P trend = 0.86P trend = 0.81P trend = 0.02
Amountb
 Never122 (35.78)Referent67 (22.11)Referent53 (19.63)Referent136 (36.36)Referent
 Light51 (14.96)1.39 (0.72–2.69)0.3343 (14.19)0.45 (0.17–1.23)0.1244 (16.30)0.70 (0.29–1.68)0.4250 (13.37)1.08 (0.54–2.18)0.83
 Moderate42 (12.32)1.81 (0.95–3.45)0.0753 (17.49)0.98 (0.46–2.08)0.9648 (17.78)1.08 (0.50–2.33)0.8547 (12.57)1.56 (0.82–2.97)0.18
 Heavy117 (34.31)1.59 (0.94–2.67)0.08131 (43.23)1.15 (0.64–2.07)0.64112 (41.48)1.01 (0.53–1.94)0.98136 (36.36)1.65 (1.02–2.67)0.04
 Unknown9 (2.64)9 (2.97)13 (4.81)5 (1.34)
P trend = 0.07P trend = 0.30P trend = 0.71P trend = 0.03
Drink-yearsc
 0122 (35.78)Referent67 (22.11)Referent53 (19.63)Referent136 (36.36)Referent
 0.1–54.976 (22.29)1.45 (0.81–2.59)0.2165 (21.45)0.74 (0.35–1.56)0.4258 (21.48)0.78 (0.36–1.71)0.5383 (22.19)1.34 (0.76–2.35)0.31
 55–159.971 (20.82)1.87 (1.06–3.29)0.0370 (23.10)0.76 (0.37–1.58)0.4767 (24.81)1.22 (0.61–2.46)0.5774 (19.79)1.19 (0.65–2.19)0.57
 160 or more58 (17.01)1.50 (0.80–2.78)0.2081 (26.73)1.38 (0.74–2.58)0.3169 (25.56)0.95 (0.46–1.95)0.8870 (18.72)2.04 (1.19–3.49)0.01
 Unknown14 (4.11)20 (6.60) 23 (8.52)11 (2.94)
P trend = 0.09P trend = 0.23P trend = 0.81P trend = 0.02
  • aHR and 95% CI were calculated using Cox proportional hazards model.

  • bLight: < 14 g/day; moderate: 14–42 g/day; heavy: > 42 g/day.

  • c1 drink-year = 1 drink (14 grams of alcohol) per day × 1 year.