Table 2.

The association between prediagnosis alcohol use and the OS of HNC patients

Model 1Model 2Model 3Model 4
Prediagnosis alcohol usen (%)HR (95% CI)a unadjustedPHR (95% CI)a adjusted for stagePHR (95% CI)a adjusted for stage and gradePHR (95% CI)a adjusted for stage, grade, and treatmentP
Never + occasional239 (32.30)ReferentReferentReferent
Former99 (13.38)1.78 (1.14–2.79)0.011.53 (0.97–2.40)0.071.54 (0.98–2.42)0.061.54 (0.98–2.43)0.06
Current402 (54.32)1.38 (0.98–1.94)0.071.23 (0.87–1.74)0.241.25 (0.89–1.77)0.201.16 (0.82–1.65)0.40
Former + current501 (67.70)1.45 (1.04–2.02)0.031.29 (0.92–1.79)0.131.31 (0.94–1.83)0.121.24 (0.88–1.73)0.22
Frequency
 Never214 (28.92)ReferentReferentReferent
 Monthly25 (3.38)0.34 (0.08–1.39)0.130.37 (0.09–1.52)0.170.42 (0.10–1.75)0.230.41 (0.10–1.72)0.22
 Weekly75 (10.14)1.21 (0.71–2.07)0.481.14 (0.67–1.95)0.631.14 (0.66–1.94)0.641.00 (0.57–1.74)1.00
 Daily408 (55.14)1.41 (1.00–1.98)0.051.24 (0.88–1.75)0.221.28 (0.90–1.81)0.171.21 (0.85–1.72)0.29
 Unknown18 (2.43)
P trend = 0.03P trend = 0.15P trend = 0.11P trend = 0.20
Amountb
 Never198 (29.69)ReferentReferentReferentReferent
 Light97 (14.54)0.98 (0.57–1.68)0.950.86 (0.50–1.47)0.570.93 (0.54–1.59)0.780.85 (0.49–1.47)0.56
 Moderate95 (14.24)1.43 (0.88–2.34)0.151.17 (0.71–1.90)0.541.12 (0.68–1.85)0.661.13 (0.68–1.88)0.64
 Heavy259 (38.83)1.46 (0.99–2.14)0.051.25 (0.85–1.84)0.251.23 (0.83–1.82)0.301.13 (0.76–1.68)0.54
 Unknown18 (2.70)
P trend = 0.03P trend = 0.15P trend = 0.22P trend = 0.38
Drink-yearsc
 0198 (29.69)ReferentReferentReferentReferent
 0.1–54.9145 (21.74)1.16 (0.74–1.82)0.531.02 (0.65–1.61)0.921.08 (0.68–1.70)0.750.99 (0.62–1.57)0.95
 55–159.9144 (21.59)1.31 (0.84–2.05)0.241.10 (0.70–1.72)0.691.02 (0.64–1.61)0.941.00 (0.63–1.60)0.99
 160 or more146 (21.89)1.63 (1.07–2.49)0.021.38 (0.90–2.11)0.141.37 (0.89–2.09)0.151.23 (0.79–1.89)0.36
 Unknown34 (5.10)
P trend = 0.02P trend = 0.13P trend = 0.19P trend = 0.36
  • Abbreviation: N, number.

  • aHR and 95% CI were calculated using Cox proportional hazards model.

  • bLight: < 14 g/day; moderate: 14–42 g/day; heavy: > 42 g/day.

  • c1 drink-year = 1 drink (14 g of alcohol) per day x 1 year.