Table 5.

The OS of HNC patients by prediagnosis alcohol drinking status and combinations of ADH1B and ALDH2 genotypes

Prediagnosis alcohol useADH1B and ALDH2 genotype combinationn (%)HR (95% CI)aP
Never + occasionalGroup 1: Fast ADH1B (*2/*2) + Fast ALDH2 (*1/*1)43 (6.00)Referent
Never + occasionalGroup 2: Fast ADH1B (*2/*2) + Slow ALDH2 (*1/*2+*2/*2)94 (13.11)0.69 (0.31–1.53)0.36
Never + occasionalGroup 3: Slow ADH1B (*1/*1 +*1/*2) + Fast ALDH2 (*1/*1)26 (3.63)0.96 (0.35–2.64)0.93
Never + occasionalGroup 4: Slow ADH1B (*1/*1 +*1/*2) + Slow ALDH2 (*1/*2+*2/*2)67 (9.34)0.90 (0.40–2.01)0.80
EverGroup 1: Fast ADH1B (*2/*2) + Fast ALDH2 (*1/*1)122 (17.02)1.13 (0.56–2.29)0.73
EverGroup 2: Fast ADH1B (*2/*2) + Slow ALDH2 (*1/*2 +*2/*2)111 (15.48)1.77 (0.89–3.52)0.11
EverGroup 3: Slow ADH1B (*1/*1 +*1/*2)+ Fast ALDH2 (*1/*1)111 (15.48)0.90 (0.43–1.88)0.78
EverGroup 4: Slow ADH1B (*1/*1 +*1/*2)+ Slow ALDH2 (*1/*2+*2/*2)143 (19.94)0.98 (0.49–1.99)0.96
Ever alcohol drinkers + Group 2: Fast ADH1B (*2/*2) + Slow ALDH2 (*1/*2 +*2/*2) vs. all others1.88 (1.33–2.64)0.0003
  • aHR and 95% CI were calculated using Cox proportional hazards model.