Table 1.

Personal and family characteristics of the WAS volunteers, for all volunteers with ½ or higher Ashkenazi-Jewish (AJ) ancestry, women under 40, and women 40 or older

Age group and characteristicMutation carriersMutation noncarriers
All ages (n)1024,487
Personal history of cancer (women) (n)2331.1%2186.9%
No cancer in reported family (n)2726.5%2,54656.7%
No cancer in 1DRs, cancer in 2DRs (n)3736.3%1,17726.2%
Cancer in 1DRs (n)3837.3%76417.0%
Age (median, IQR)4813.755018
½ AJ ancestry (n)1110.8%59713.3%
¾ AJ ancestry (n)1514.7%4329.6%
Number of cancer-free female relatives (mean, SD)3.51.53.71.4
Sex (n female)7472.5%3,17670.8%
BRCA1: 185delAG320.70%-
BRCA2: 5382insC180.39%-
BRCA2: 6174delT521.13%-
Women <40 (n)1716.7%58913.1%
Personal history of cancer (n)211.8%30.5%
No cancer in reported family (n)423.5%33256.4%
No cancer in 1DRs, cancer in 2DRs (n)529.4%15426.1%
Cancer in 1DRs (n)847.1%10317.5%
Age (median, IQR)365338
½ AJ ancestry (n)317.6%6611.2%
¾ AJ ancestry (n)317.6%478.0%
Number of cancer-free female relatives (mean, SD)3.21.73.61.3
Women >40 (n)5755.9%2,58757.7%
Personal history of cancer (n)2136.8%2158.3%
No cancer in reported family (n)1322.8%1,34552.0%
No cancer in 1DRs, cancer in 2DRs (n)2442.1%75429.1%
Cancer in 1DRs (n)2035.1%48818.9%
Age (median, IQR)52125216
½ AJ ancestry (n)35.3%35113.6%
¾ AJ ancestry (n)47.0%2429.4%
Number of cancer-free female relatives (mean, SD)3.61.33.81.4
  • NOTE: Characteristics given: Number and proportion of women with a personal history of cancer; Number and proportion of volunteers with no cancer reported in their family; Number and proportion of volunteers with no cancer reported among first-degree relatives (1DRs; mother, sisters, daughters) and cancer reported among second-degree relatives (2DRs; grandmothers, aunts); Number and proportion of volunteers with cancer reported among first-degree relatives (1DRs); Median and intraquartile range (IQR) volunteer age; Number and proportion of volunteers with ½ or ¾ AJ ancestry; Mean and SD number of cancer-free first- and second-degree female relatives; Number and proportion of female volunteers.