Table 2.

Meta-regression results

MatchingaThresholdingbAdjustmentcInvasived
Continuous PMDEmbedded Image (95% CI)0.0114 (0.0012–0.0206)
OR intercept (95% CI)1.0847 (1.0422–1.1549)
OR incl. Embedded Image (95% CI)1.0972 (1.0435–1.1790)
Categorical PMD: 25%–50%Embedded Image (95% CI)0.4077 (0.1726–0.6443)0.3051 (0.0213–0.5408)
OR intercept (95% CI)1.4475 (1.173–1.7678)1.5928 (1.2995–2.0009)
OR incl. Embedded Image (95% CI)2.1760 (1.3873–3.3904)2.1611 (1.3256–3.4764)
Categorical PMD: 50%–75%Embedded Image (95% CI)0.5118 (0.1698–0.8712)0.4242 (0.0277–0.7616)0.4284 (0.0453–0.7673)−0.3970 (-0.8094–0.0001)
OR intercept (95% CI)1.6468 (1.223–2.2797)1.9034 (1.4004–2.5696)1.9073 (1.3548–2.5157)3.3720 (2.3980–4.7325)
OR incl. Embedded Image (95% CI)2.7465 (1.4359–5.4943)2.9090 (1.4584–5.6765)2.9273 (1.4044–5.4690)2.2670 (1.0612–4.8141)
  • aMatching is defined as use of matched case–control study setup; reference category: no matching.

  • bThresholding is defined as use of an automatic thresholding program; reference category: no use of automatic thresholding.

  • cAdjustment is defined as inclusion of confounders, at a minimum age and/or body mass index (BMI); reference category: no adjustment.

  • dInvasive is defined as invasive cancer type; reference category: noninvasive cancer.